Antidiabetic effects of extracts from Psidium guajava']java

被引：125

作者：

Oh, WK

Lee, CH

Lee, MS

Bae, EY

Sohn, CB

Oh, H

Kim, BY

Ahn, JS

机构：

[1] KRIBB, Taejon 305600, South Korea

[2] Chungnam Natl Univ, Dept Food & Nutr, Taejon 305764, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 03期

关键词：

Psidium gua[!text type='java']java[!/text; type; 2; diabetes; PTP1B; Lepr(db)/Lepr(db) mice; blood glucose;

D O I：

10.1016/j.jep.2004.09.041

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db) mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db) mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr(db)/Lepr(db) mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：411 / 415

页数：5

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