Lipid phosphatases in the immune system

被引：115

作者：

Krystal, G ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

SHIP; SHIP2; PTEN; proliferation; apoptosis;

D O I：

10.1006/smim.2000.0222

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-4,5-P-3 plays in regulating a vast array of biological responses to extracellular signals. The level of this phospholipid is low in resting cells but increases rapidly in response to growth factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase. Within the last 3 years three enzymes, SHIP: SHIP2 and PTEN, that play hey roles in regulating the level of PI-3,4,5-P3 have been cloned. In this review I have attempted to summarize our current knowledge regarding these three intriguing phosphatases.

引用

页码：397 / 403

页数：7

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