A domino copper-catalyzed C-O coupling-Claisen rearrangement process

被引：180

作者：

Nordmann, G ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 17期

关键词：

D O I：

10.1021/ja034809y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical method for the diastereoselective generation of two adjacent quarternary stereocenters by combining a copper-catalyzed C-O coupling reaction with a subsequent Claisen rearrangement in a one-pot domino process is described. Furthermore, an experimentally simple method for the stereoselective synthesis of a variety of different types of vinyl ethers is delineated using the same catalyst system. Copyright © 2003 American Chemical Society.

引用

页码：4978 / 4979

页数：2

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