2-(4-Sulfophenyisulfonyl)ethoxycarbonyl group:: a new water-soluble N-protecting group and its application to solid phase peptide synthesis in water

被引：36
作者：
Hojo, K [1 ]
Maeda, M [1 ]
Kawasaki, K [1 ]
机构：
[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期
关键词：
2-(4-Sulfophenyisulfonyl)ethoxycarbonyl group; water-soluble N-protecting group; peptide synthesis in water;
D O I：
10.1016/j.tetlet.2004.10.095
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Solid phase peptide synthesis is carried out in organic solvents, creating environmental problems after disposal. To avoid this problem, we aimed to perform solid phase peptide synthesis in water. A new water-soluble N-protecting group, 2-(4-sulfophenylsulfonyl)ethoxycarbonyl (Sps) group, was designed and Sps-amino acids were prepared. To evaluate the utility of this technique, Leu-enkephalin amide was prepared by solid phase synthesis using Sps-ainino acids in water. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：9293 / 9295
页数：3
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