Wall shear stress fixed points in cardiovascular fluid mechanics

被引:69
作者
Arzani, Amirhossein [1 ]
Shadden, Shawn C. [2 ]
机构
[1] No Arizona Univ, Mech Engn Dept, Flagstaff, AZ 86011 USA
[2] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA
基金
美国国家科学基金会;
关键词
Blood flow; Hemodynamics; Mass transport; Endothelial cells; ENDOTHELIAL-CELL LAYER; IMPINGING FLOW; COMPUTATIONAL HEMODYNAMICS; ARTERIAL BIFURCATION; CEREBRAL ANEURYSMS; TURBULENT FLOWS; ASCENDING AORTA; PULSATILE FLOW; BLOOD-FLOW; SEPARATION;
D O I
10.1016/j.jbiomech.2018.03.034
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Complex blood flow in large arteries creates rich wall shear stress (WSS) vectorial features. WSS acts as a link between blood flow dynamics and the biology of various cardiovascular diseases. WSS has been of great interest in a wide range of studies and has been the most popular measure to correlate blood flow to cardiovascular disease. Recent studies have emphasized different vectorial features of WSS. However, fixed points in the WSS vector field have not received much attention. A WSS fixed point is a point on the vessel wall where the WSS vector vanishes. In this article, WSS fixed points are classified and the aspects by which they could influence cardiovascular disease are reviewed. First, the connection between WSS fixed points and the flow topology away from the vessel wall is discussed. Second, the potential role of time-averaged WSS fixed points in biochemical mass transport is demonstrated using the recent concept of Lagrangian WSS structures. Finally, simple measures are proposed to quantify the exposure of the endothelial cells to WSS fixed points. Examples from various arterial flow applications are demonstrated. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码:145 / 152
页数:8
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