Electrospun Poly(L-Lactide-co-ε-Caprolactone)/Polyethylene Oxide/Hydroxyapaite Nanofibrous Membrane for Guided Bone Regeneration

被引：6

作者：

Wang, Gang ^{[1
]}

Ren, Tianbin ^{[1
]}

Cao, Chunhong ^{[1
]}

Yuan, Weizhong ^{[1
]}

Song, Ying ^{[1
]}

Su, Jiansheng ^{[2
]}

机构：

[1] Tongji Univ, Inst Nano & Biopolymer Mat, Sch Mat Sci & Engn, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Stomatol, Shanghai 200092, Peoples R China

来源：

JOURNAL OF NANOMATERIALS | 2010年 / 2010卷

基金：

中国国家自然科学基金;

关键词：

TISSUE REGENERATION; POLY(EPSILON-CAPROLACTONE); PROLIFERATION; COLLAGEN;

D O I：

10.1155/2010/232017

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A series of poly(L-lactide-co-e-caprolactone)/polyethylene oxide/hydroxyapaite (PLCL/PEO/HA) composite fibrous membranes were prepared by elecrospinning technology for guided bone regeneration. The morphology, water permeability and mechanical properties of the membranes were investigated. The HA nanocrystals can be well distributed in the PLCL/PEO matrix. And the diameter of composite nanofiber is larger than that of pure PLCL. The fibers with uniform size and large diameter were obtained when the contents of PEO and HA were 0.4% and 0.03%, respectively. In this condition, the obtained membrane presents the best water permeability. Furthermore, the nanofibrous membrane with largest tensile strength was obtained when the contents of PEO and HA were 0.5% and 0.03%, respectively.

引用

页数：8

共 34 条

[1] GUIDED TISSUE REGENERATION - COMPARISON OF BIOABSORBABLE AND NON-BIOABSORBABLE MEMBRANES - HISTOLOGIC AND HISTOMETRIC STUDY IN DOGS [J].

CAFFESSE, RG ;

NASJLETI, CE ;

MORRISON, EC ;

SANCHEZ, R .

JOURNAL OF PERIODONTOLOGY, 1994, 65 (06) :583-591

[2] Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide) [J].

Duan, B ;

Dong, CH ;

Yuan, XY ;

Yao, KD .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2004, 15 (06) :797-811

[3] Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers [J].

Fujihara, K ;

Kotaki, M ;

Ramakrishna, S .

BIOMATERIALS, 2005, 26 (19) :4139-4147

[4] Fast degradable poly(L-lactide-co-ε-caprolactone) microspheres for tissue engineering:: Synthesis, characterization, and degradation behavior [J].

Garkhal, Kalpna ;

Verma, Shalini ;

Jonnalagadda, S. ;

Kumar, Neeraj .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2007, 45 (13) :2755-2764

[5] Double-layered composite nanofibers and their mechanical performance [J].

Huang, ZM ;

Zhang, YZ ;

Ramakrishna, S .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2005, 43 (20) :2852-2861

[6] Development of guided bone regeneration membrane composed of β-tricalcium phosphate and poly (L-lactide-co-glycolide-ε-caprolactone) composites [J].

Kikuchi, M ;

Koyama, Y ;

Yamada, T ;

Imamura, Y ;

Okada, T ;

Shirahama, N ;

Akita, K ;

Takakuda, K ;

Tanaka, J .

BIOMATERIALS, 2004, 25 (28) :5979-5986

[7] Electrospinning biomedical nanocomposite fibers of hydroxyapaite/poly(lactic acid) for bone regeneration [J].

Kim, Hae-Won ;

Lee, Hae-Hyoung ;

Knowles, J. C. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 79A (03) :643-649

[8] Nanoriber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration [J].

Kim, HW ;

Song, JH ;

Kim, HE .

ADVANCED FUNCTIONAL MATERIALS, 2005, 15 (12) :1988-1994

[9] Electrospun nanofibers composed of poly(ε-caprolactone) and polyethylenimine for tissue engineering applications [J].

Kim, Jang Ho ;

Choung, Pill-Hoon ;

Kim, In Yong ;

Lim, Ki Taek ;

Son, Hyun Mok ;

Choung, Yun-Hoon ;

Cho, Chong-Su ;

Chung, Jong Hoon .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2009, 29 (05) :1725-1731

[10] Guided tissue regeneration for using a chitosan membrane: An experimental study in rats [J].

Kuo, SM ;

Chang, SJ ;

Chen, TW ;

Kuan, TC .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 76A (02) :408-415

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