Volumetric monitoring of aqueous two phase system droplets using time-lapse optical coherence tomography

被引：5
作者：
Lee, J. [1 ]
Bathany, C. [2 ]
Ahn, Y. [3 ,4 ]
Takayama, S. [2 ]
Jung, W. [1 ,5 ]
机构：
[1] UNIST, Dept Biomed Engn, Ulsan 44919, South Korea
[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[3] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea
[4] Ctr Marine Integrated Biomed Technol, Busan 48513, South Korea
[5] IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea
来源：
LASER PHYSICS LETTERS | 2016年 / 13卷 / 02期
关键词：
optical coherence tomography; aqueous two phase system; droplet; microfluidics;
D O I：
10.1088/1612-2011/13/2/025606
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present a volumetric monitoring method to observe the morphological changes of aqueous two phase system (ATPS) droplets in a microfluidic system. Our method is based on time-lapse optical coherence tomography (OCT) which allows the study of the dynamics of ATPS droplets while visualizing their 3D structures and providing quantitative information on the droplets. In this study, we monitored the process of rehydration and deformation of an ATPS droplet in a microfluidic system and quantified the changes of its volume and velocity under both static and dynamic fluid conditions. Our results indicate that time-lapse OCT is a very promising tool to evaluate the unprecedented features of droplet-based microfluidics.
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页数：5
相关论文
共 14 条
  • [1] Optical sectioning for microfluidics: secondary flow and mixing in a meandering microchannel
    Ahn, Yeh-Chan
    Jung, Woonggyu
    Chen, Zhongping
    [J]. LAB ON A CHIP, 2008, 8 (01) : 125 - 133
  • [2] Albertsson P.A., 1986, PARTITION CELL PARTI
  • [3] Dehydrated aqueous two-phase system micro-domains retain their shape upon rehydration to allow patterned reagent delivery to cells
    Bathany, Cedric
    Park, Juhee
    Cho, Yoon-Kyoung
    Takayama, Shuichi
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2013, 1 (44) : 6020 - 6026
  • [4] Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography
    deBoer, JF
    Milner, TE
    vanGemert, MJC
    Nelson, JS
    [J]. OPTICS LETTERS, 1997, 22 (12) : 934 - 936
  • [5] Wettability characterization method based on optical coherence tomography imaging
    Fabritius, Tapio
    Myllyla, Risto
    Makita, Shuichi
    Yasuno, Yoshiaki
    [J]. OPTICS EXPRESS, 2010, 18 (22): : 22859 - 22866
  • [6] OPTICAL COHERENCE TOMOGRAPHY
    HUANG, D
    SWANSON, EA
    LIN, CP
    SCHUMAN, JS
    STINSON, WG
    CHANG, W
    HEE, MR
    FLOTTE, T
    GREGORY, K
    PULIAFITO, CA
    FUJIMOTO, JG
    [J]. SCIENCE, 1991, 254 (5035) : 1178 - 1181
  • [7] 4D embryonic cardiography using gated optical coherence tomography
    Jenkins, MW
    Rothenberg, F
    Roy, D
    Nikolski, VP
    Hu, Z
    Watanabe, M
    Wilson, DL
    Efimov, IR
    Rollins, AM
    [J]. OPTICS EXPRESS, 2006, 14 (02): : 736 - 748
  • [8] Concentration Dependence of the Interfacial Tension for Aqueous Two-Phase Polymer Solutions of Dextran and Polyethylene Glycol
    Liu, Yonggang
    Lipowsky, Reinhard
    Dimova, Rumiana
    [J]. LANGMUIR, 2012, 28 (08) : 3831 - 3839
  • [9] Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues
    Rogowska, J
    Patel, NA
    Fujimoto, JG
    Brezinski, ME
    [J]. HEART, 2004, 90 (05) : 556 - 562
  • [10] Srinivasan V, 2003, 7 INT C MICR AN SYST, P1303
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