The synthesis of highly substituted decahydrocarbazoles as potential chain-breaking antioxidants

被引：0

作者：

Brown, DW ^{[1
]}

Sainsbury, M ^{[1
]}

Sibley, GFM ^{[1
]}

Wood, VA ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 2000年 / 06期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two methyl groups have been introduced into the positions a to the N-atom in 1,2,3,4,4a,5,6,7-octahydrobenzo [d]carbazoles in a 'one-pot' procedure; additionally bromination of 1H-2,3,4,4a-tetrahydro-6-isopropylcarbazoles has been shown to occur at C-8 and the derived bromides converted into 8-alkenylated derivatives as precursors of chain-breaking antioxidants of tuneable lipophilicity.

引用

页码：304 / 306

页数：3

共 8 条

[1] [Anonymous], 1990, CHOLESTEROL ATHEROSC
[2] NEW ANTIOXIDANTS INCORPORATING INDOLE AND INDOLINE CHROMOPHORES
BROWN, DW
GRAUPNER, PR
SAINSBURY, M
SHERTZER, HG
[J]. TETRAHEDRON, 1991, 47 (25) : 4383 - 4408
[3] The synthesis of antioxidants showing selective affinity for low density lipoproteins
Brown, DW
Mahon, MF
Ninan, A
Sainsbury, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (16): : 2329 - 2336
[4] Indolisation of 1-decalone and the reactions of the products with oxygen and with nucleophiles
Brown, DW
Mahon, MF
Ninan, A
Sainsbury, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (11): : 1699 - 1706
[5] AN ALTERNATIVE ROUTE TO 2-SUBSTITUTED INDOLES VIA N-AMINAL-DIRECTED LITHIATION
KATRITZKY, AR
LUE, P
CHEN, YX
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (11) : 3688 - 3691
[6] CARBON-DIOXIDE - A REAGENT FOR SIMULTANEOUS PROTECTION OF NUCLEOPHILIC CENTERS AND THE ACTIVATION OF ALTERNATIVE LOCATIONS TO ELECTROPHILIC ATTACK .10. ALPHA-METALLATION OF TETRAHYDROQUINOLINE AND INDOLINE VIA THEIR LITHIUM CARBAMATES - A VERSATILE ONE-POT PROCEDURE
KATRITZKY, AR
SENGUPTA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (01): : 17 - 19
[7] CARBON-DIOXIDE - A REAGENT FOR THE PROTECTION OF NUCLEOPHILIC CENTERS AND THE SIMULTANEOUS ACTIVATION OF ALTERNATIVE LOCATIONS TO ELECTROPHILIC ATTACK .1. A NEW SYNTHETIC METHOD FOR THE 2-SUBSTITUTION OF 1-UNSUBSTITUTED INDOLES
KATRITZKY, AR
AKUTAGAWA, K
[J]. TETRAHEDRON LETTERS, 1985, 26 (48) : 5935 - 5938
[8] Characterization of novel indenoindoles .1. Structure-activity relationships in different model systems of lipid peroxidation
Westerlund, C
OstlundLindqvist, AM
Sainsbury, M
Shertzer, HG
Sjoquist, PO
[J]. BIOCHEMICAL PHARMACOLOGY, 1996, 51 (10) : 1397 - 1402

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