The functions of RPS19 and their relationship to Diamond-Blackfan anemia: A review

被引：14

作者：

Morimoto, Kenji ^{[1
]}

Lin, Shou

Sakamoto, Kathleen

机构：

[1] Univ Calif Los Angeles, Mattel Childrens Hosp, Dept Pediat, Div Hematol Oncol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Gwynne Hazen Cherry Mem Labs, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[4] CALTECH, Div Biol, Pasadena, CA 91125 USA

[5] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2007年 / 90卷 / 04期

关键词：

Diamond-Blackfan anemia; congenital anemia; RPS19; ribosomal biogenesis; ribosomal proteins; erythropoiesis; RNA processing;

D O I：

10.1016/j.ymgme.2006.11.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relatively new study of ribosomal proteins has allowed for greater understanding of protein synthesis; however the connection between ribosomal proteins' roles and that of disease pathophysiology has not yet been established. RPS19 is a ribosomal protein linked to Diamond Blackfan anemia whose functions have begun to be elucidated. We review here the known roles of RPS19 in both ribosome construction and other extra-ribosomal functions and discuss their relationship to Diamond-Blackfan anemia. (c) Published by Elsevier Inc.

引用

页码：358 / 362

页数：5

共 49 条

[1] The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C [J].