Compounds with neuroprotective activity from the medicinal plant Machilus thunbergii

被引：21

作者：

Ma, Choong Je ^{[3
]}

Kim, Young Choong ^{[1
,2
]}

Sung, Sang Hyun ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[3] Kangwon Natl Univ, Sch Biosci & Biotechnol, Chunchon 200701, South Korea

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2009年 / 24卷 / 05期

关键词：

Machilus thunbergii; Tyrosol; Neuroprotective; Antioxidant; RAT CORTICAL-CELLS; PRIMARY CULTURES; OLIVE OIL; LIGNANS; RECEPTORS; PROTECT; CONSTITUENTS; BARK;

D O I：

10.1080/14756360802632971

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dichloromethane fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. Through the activity-guided isolation from the CH2Cl2 fraction, (+)-9'-hydroxygalbelgin (1), isogalcatin B (2), (7S,8S,8'R)3',4'-dimethoxy-3,4,-methylenedioxylignan-7-ol (3), 1-hydroxy-7-hydroxymethyl-6-methoxyxanthone (4), 5,7dimethoxy-3',4'-methylenedioxyflavan-3-ol (5), (+)-(3S,4S,6R)-3,6-dihydroxypiperitone (6), protocatechuic acid methyl ester (7) and tyrosol (8) were obtained. All of them had significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at concentrations ranging from 0.1 mu M to 10.0 mu M and were comparable to MK-801, a well-known inhibitor of glutamate receptor.

引用

页码：1117 / 1121

页数：5

共 26 条

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