Granulocyte Colony-stimulating Factor-induced Aortitis with Lung Injury, Splenomegaly, and a Rash During Treatment for Recurrent Extraosseous Mucinous Chondrosarcoma

被引：6

作者：

Kametani, Takahiro ^{[1
]}

Otani, Yuichiro ^{[1
]}

Ohigashi, Toshikazu ^{[2
]}

Kubo, Tadahiko ^{[3
]}

Sakuda, Tomohiko ^{[3
]}

Furuta, Daisuke ^{[3
]}

Ito, Yayoiko ^{[1
]}

Shigenobu, Yuya ^{[1
]}

Kakimoto, Masaki ^{[1
]}

Kawahara, Akihiro ^{[1
]}

Kikuchi, Yuka ^{[1
]}

Kobayashi, Tomoki ^{[1
]}

Miyamori, Daisuke ^{[1
]}

Kishikawa, Nobusuke ^{[1
]}

Kanno, Keishi ^{[1
]}

Ito, Masanori ^{[1
]}

机构：

[1] Hiroshima Univ Hosp, Dept Gen Internal Med, Hiroshima, Japan

[2] Hiroshima Univ Hosp, Dept Pharmaceut Serv, Hiroshima, Japan

[3] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Orthopaed Surg, Higashihiroshima, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 08期

关键词：

G-CSF; aortitis; pegfilgrastim; sarcoma; CHEMOTHERAPY; JAPAN; FEVER; BONE;

D O I：

10.2169/internalmedicine.5913-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient's underlying diseases or therapeutic pharmacological backgrounds.

引用

页码：1311 / 1315

页数：5

共 24 条

[1] [Anonymous], 2019, FITZPATRICKS DERMATO, V9th, P3483
[2] Granulocyte colony-stimulating factor or neutrophil-induced pulmonary toxicity: Myth or reality? Systematic review of clinical case reports and experimental data
Azoulay, E
Attalah, H
Harf, A
Schlemmer, B
Delclaux, C
[J]. CHEST, 2001, 120 (05) : 1695 - 1701
[3] Neutrophilic eccrine hidradenitis
Bachmeyer, C
Aractingi, S
[J]. CLINICS IN DERMATOLOGY, 2000, 18 (03) : 319 - 330
[4] Bachmeyer C, 1998, BRIT J DERMATOL, V139, P354
[5] Infection and vasculitis
Belizna, Cristina C.
Hamidou, Mohamed A.
Levesque, Herve
Guillevin, Loic
Shoenfeld, Yehuda
[J]. RHEUMATOLOGY, 2009, 48 (05) : 475 - 482
[6] Cancer Registry and Statistics, CANC INF SERV
[7] REDUCTION BY GRANULOCYTE COLONY-STIMULATING FACTOR OF FEVER AND NEUTROPENIA INDUCED BY CHEMOTHERAPY IN PATIENTS WITH SMALL-CELL LUNG-CANCER
CRAWFORD, J
OZER, H
STOLLER, R
JOHNSON, D
LYMAN, G
TABBARA, I
KRIS, M
GROUS, J
PICOZZI, V
RAUSCH, G
SMITH, R
GRADISHAR, W
YAHANDA, A
VINCENT, M
STEWART, M
GLASPY, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (03) : 164 - 170
[8] Impact of primary prophylaxis with granulocyte colony-stimulating factor on febrile neutropenia and mortality in adult cancer patients receiving chemotherapy: A systematic review
Kuderer, Nicole M.
Dale, David C.
Crawford, Jeffrey
Lyman, Gary H.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (21) : 3158 - 3167
[9] Granulocyte colony-stimulating factors and aortitis: A rare adverse event
Lardieri, Allison
McCulley, Lynda
Jones, Steven Christopher
Woronow, Daniel
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (10) : E333 - E336
[10] Lisukov IA, 1998, TERAPEVT ARKH, V70, P78

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