TCR-engineered T cells to treat tumors: Seeing but not touching?

被引：58

作者：

Debets, Reno ^{[1
]}

Donnadieu, Emmanuel ^{[2
,3
,4
,5
]}

Chouaib, Salem ^{[6
]}

Coukos, George ^{[7
]}

机构：

[1] Erasmus MC Canc Inst, Dept Med Oncol, Lab Tumor Immunol, Off Be-430b,Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands

[2] Inst Cochin, Inserm U1016, Paris, France

[3] CNRS, UMR8104, Paris, France

[4] Univ Paris 05, Paris, France

[5] Equipe Labellisee Ligue Canc, Paris, France

[6] INSERM, U1186, Equipe Labellisee Ligue Canc, Gustave Roussy Campus, Villejuif, France

[7] Univ Lausanne, Univ Hosp Lausanne CHUV, Dept Oncol, CH-1015 Lausanne, Switzerland

来源：

SEMINARS IN IMMUNOLOGY | 2016年 / 28卷 / 01期

关键词：

Antigen recognition; Immune evasion; T cell; T cell receptor; T cell trafficking; Tumor micro-environment; FIBROBLAST ACTIVATION PROTEIN; ACUTE MYELOID-LEUKEMIA; RECEPTOR GENE-THERAPY; SUPPRESSOR-CELLS; STROMAL CELLS; CANCER REGRESSION; INTRATUMORAL INFILTRATION; CARDIOVASCULAR TOXICITY; MATRIX ARCHITECTURE; COLORECTAL CANCERS;

D O I：

10.1016/j.smim.2016.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adoptive transfer of T cells gene-engineered with T cell receptors (TCRs) has proven its feasibility and therapeutic potential in the treatment of malignant tumors. To ensure further clinical development of TCR gene therapy, it is necessary to accurately select TCRs that demonstrate antigen-selective responses that are restricted to tumor cells and, at the same time, include strategies that restore or enhance the entry, migration and local accumulation of T cells in tumor tissues. Here, we present the current standing of TCRengineered T cell therapy, discuss and propose procedures to select TCRs as well as strategies to sensitize the tumor to T cell trafficking, and provide a rationale for combination therapies with TCR-engineered T cells. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：10 / 21

页数：12

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