MUC1: Structure, Function, and Clinic Application in Epithelial Cancers

被引：185

作者：

Chen, Wenqing ^{[1
]}

Zhang, Zhu ^{[2
]}

Zhang, Shiqing ^{[2
]}

Zhu, Peili ^{[2
]}

Ko, Joshua Ka-Shun ^{[1
]}

Yung, Ken Kin-Lam ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Sch Chinese Med, Div Teaching & Res, Hong Kong, Peoples R China

[2] Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 12期

关键词：

MUC1; epithelial cancer; MUC1 cell barrier; tumor oncogene; therapeutic biomarkers; immunotherapy; PANCREATIC DUCTAL ADENOCARCINOMA; IMMUNOLOGICAL EVALUATION; TRANSMEMBRANE MUCINS; EXTRACELLULAR DOMAIN; IMMUNE EVASION; BREAST-CANCER; DUAL ROLE; GROWTH; ONCOPROTEIN; EXPRESSION;

D O I：

10.3390/ijms22126567

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells. However, in cancer cells, MUC1 often undergoes aberrant glycosylation and overexpression. It is involved in cancer invasion, metastasis, angiogenesis, and apoptosis by virtue of its participation in intracellular signaling processes and the regulation of related biomolecules. This review introduces the biological structure and different roles of MUC1 in normal and cancer cells and the regulatory mechanisms governing these roles. It also evaluates current research progress and the clinical applications of MUC1 in cancer therapy based on its characteristics.

引用

页数：15

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