A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia

被引：123

作者：

Simonetto, Marialaura ^{[1
,2
]}

Infante, Marco ^{[3
,4
,5
]}

Sacco, Ralph L. ^{[1
,2
]}

Rundek, Tatjana ^{[1
,2
]}

Della-Morte, David ^{[1
,2
,5
,6
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Evelyn F McKnight Brain Inst, Miami, FL 33136 USA

[3] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA

[4] Univ Miami, Miller Sch Med, Clin Cell Transplant Program, Miami, FL 33136 USA

[5] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy

[6] San Raffaele Roma Open Univ, I-00166 Rome, Italy

来源：

NUTRIENTS | 2019年 / 11卷 / 10期

关键词：

omega-3; PUFAs; omega-6; inflammation; resolvins; AA; EPA ratio; atherosclerosis; cardiovascular risk; neurodegeneration; vascular cognitive impairment and dementia; ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; FISH-OIL SUPPLEMENTATION; LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; RED-BLOOD-CELLS; AGED; 45-70; Y; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID;

D O I：

10.3390/nu11102279

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to vascular diseases, such as stroke and myocardial infarction. The relationship between atherosclerosis and risk of neurodegeneration has been established, in particular with vascular cognitive impairment and dementia (VCID). Systemic atherosclerosis increases the risk of VCID by inducing cerebral infarction, or through systemic or local inflammatory factors that underlie both atherosclerosis and cognition. Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are involved in inflammatory processes, but with opposite roles. Specifically, omega-3 PUFAs exert anti-inflammatory properties by competing with omega-6 PUFAs and displacing arachidonic acid in membrane phospholipids, decreasing the production of pro-inflammatory eicosanoids. Experimental studies and some clinical trials have demonstrated that omega-3 PUFA supplementation may reduce the risk of different phenotypes of atherosclerosis and cardiovascular disease. This review describes the link between atherosclerosis, VCID and inflammation, as well as how omega-3 PUFA supplementation may be useful to prevent and treat inflammatory-related diseases.

引用

页数：28

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