Cellular and chemical neuroscience of mammalian sleep

被引：60
作者：
Datta, Subimal [1 ,2 ,3 ]
机构：
[1] Boston Univ, Sch Med, Lab Sleep & Cognit Neurosci, Dept Psychiat, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Lab Sleep & Cognit Neurosci, Dept Neurol, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Lab Sleep & Cognit Neurosci, Dept Neurosci, Boston, MA 02118 USA
来源：
SLEEP MEDICINE | 2010年 / 11卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Wakefulness; Slow-wave sleep; Rapid eye movement sleep; Wake-promoting structures of the brain; Metabolite homeostasis; Cellular-molecular-network model; Neurotransmitters; Intracellular signal transduction; HORMONE-RELEASING-HORMONE; DEPENDENT PROTEIN-KINASE; MEDIAL PREOPTIC AREA; EYE-MOVEMENT SLEEP; WAKING DISCHARGE PATTERNS; MESOPONTINE CHOLINERGIC NUCLEI; ANTERIOR HYPOTHALAMIC NEURONS; PONTINE RETICULAR-FORMATION; SPONTANEOUS REM-SLEEP; GROWTH-HORMONE;
D O I：
10.1016/j.sleep.2010.02.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Extraordinary strides have been made toward understanding the complexities and regulatory mechanisms of sleep over the past two decades thanks to the help of rapidly evolving technologies. At its most basic level, mammalian sleep is a restorative process of the brain and body. Beyond its primary restorative purpose, sleep is essential for a number of vital functions. Our primary research interest is to understand the cellular and molecular mechanisms underlying the regulation of sleep and its cognitive functions. Here I will reflect on our own research contributions to 50 years of extraordinary advances in the neurobiology of slow-wave sleep (SWS) and rapid eye movement (REM) sleep regulation. I conclude this review by suggesting some potential future directions to further our understanding of the neurobiology of sleep. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：431 / 440
页数：10
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