Zwitterion-functionalized hollow mesoporous Prussian blue nanoparticles for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia

被引：27

作者：

Bai, Huiyuan ^{[1
,2
]}

Sun, Quanhao ^{[1
,2
]}

Kong, Fei ^{[1
,2
]}

Dong, Haijiao ^{[1
,2
]}

Ma, Ming ^{[1
,2
]}

Liu, Fangzhou ^{[4
,5
]}

Wang, Chen ^{[6
]}

Xu, Haiyan ^{[3
]}

Gu, Ning ^{[1
,2
]}

Zhang, Yu ^{[1
,2
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, Jiangsu Key Lab Biomat & Devices, State Key Lab Bioelect, Nanjing 210096, Peoples R China

[2] Southeast Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Nanjing 210096, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Beijing 100005, Peoples R China

[4] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Head & Neck Surg, Nanjing 210029, Peoples R China

[5] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Inst Canc Res, Nanjing 210029, Peoples R China

[6] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 26期

基金：

中国国家自然科学基金;

关键词：

DRUG-DELIVERY; GOLD NANORODS; IN-VITRO; EFFICIENT; THERAPY; AGENT; DOXORUBICIN; NANOSHEETS; NANOCUBES; ABLATION;

D O I：

10.1039/d1tb00548k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Multifunctional drug delivery systems combining two or more therapies have a wide-range of potential for high efficacy tumor treatment. Herein, we designed a novel hollow mesoporous Prussian blue nanoparticles (HMPBs)-based platform for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia (AML). The HMPBs were first loaded with the anticancer drugs daunorubicin (DNR) and cytarabine (AraC), and were subsequently coated with polyethylenimine (PEI) through electrostatic adsorption. Then, zwitterionic sulfobetaine (ZS) and CXCR4 antagonist peptide E5 were modified onto the surface of the nanoparticles via covalent bonding to fabricate a nanoplatform (denoted as HMPBs(DNR + AraC)@PEI-ZS-E5). The nanoplatform showed excellent photothermal effects, superior photothermal stability, reduced nonspecific protein adsorption, efficient targeting capability, a constant hydrodynamic diameter and good biocompatibility. Additionally, a laser-responsive drug release pattern was observed. In vitro results indicated that the nanoplatform could achieve active targeting and remarkable chemo-photothermal synergetic therapeutic effects, showcasing its great potential in AML treatment.

引用

页码：5245 / +

页数：11

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