Age-related macular degeneration: Complement in action

被引：57

作者：

Campagne, Menno van Lookeren ^{[1
]}

Strauss, Erich C. ^{[2
]}

Yaspan, Brian L. ^{[3
]}

机构：

[1] Genentech Inc, Dept Immunol, 1 DNA Way, San Francisco, CA 94080 USA

[2] Genentech Inc, Clin Sci, 1 DNA Way, San Francisco, CA 94080 USA

[3] Genentech Inc, Human Genet, 1 DNA Way, San Francisco, CA 94080 USA

来源：

IMMUNOBIOLOGY | 2016年 / 221卷 / 06期

关键词：

Age-related macular degeneration; Genetics; Complement; RETINAL-PIGMENT EPITHELIUM; FACTOR-H POLYMORPHISM; HIGH-RISK; GEOGRAPHIC ATROPHY; OXIDATIVE STRESS; REGULATORY PROTEINS; GENETIC-VARIANTS; CODING VARIANT; CFI GENE; FACTOR-I;

D O I：

10.1016/j.imbio.2015.11.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD. (C) 2015 The Authors. Published by Elsevier GmbH.

引用

页码：733 / 739

页数：7

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