Age-related macular degeneration: Complement in action

被引：57
作者：
Campagne, Menno van Lookeren [1 ]
Strauss, Erich C. [2 ]
Yaspan, Brian L. [3 ]
机构：
[1] Genentech Inc, Dept Immunol, 1 DNA Way, San Francisco, CA 94080 USA
[2] Genentech Inc, Clin Sci, 1 DNA Way, San Francisco, CA 94080 USA
[3] Genentech Inc, Human Genet, 1 DNA Way, San Francisco, CA 94080 USA
来源：
IMMUNOBIOLOGY | 2016年 / 221卷 / 06期
关键词：
Age-related macular degeneration; Genetics; Complement; RETINAL-PIGMENT EPITHELIUM; FACTOR-H POLYMORPHISM; HIGH-RISK; GEOGRAPHIC ATROPHY; OXIDATIVE STRESS; REGULATORY PROTEINS; GENETIC-VARIANTS; CODING VARIANT; CFI GENE; FACTOR-I;
D O I：
10.1016/j.imbio.2015.11.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD. (C) 2015 The Authors. Published by Elsevier GmbH.
引用
收藏
页码：733 / 739
页数：7
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