Rare Carbon-Bridged Citrinin Dimers from the Starfish-Derived Symbiotic Fungus Penicillium sp. GGF16-1-2

被引：23

作者：

Fan, Hao ^{[1
]}

Shi, Zhi-Mian ^{[1
]}

Lei, Yan-Hu ^{[1
]}

Si-Tu, Mei-Xia ^{[1
]}

Zhou, Feng-Guo ^{[1
]}

Feng, Chan ^{[1
]}

Wei, Xia ^{[1
]}

Shao, Xue-Hua ^{[2
]}

Chen, Yang ^{[1
]}

Zhang, Cui-Xian ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] Guangdong Acad Agr Sci, Inst Fruit Tree Res, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangdong Prov Key Lab Trop & Subtrop Fruit Tree, Guangzhou 510640, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 07期

基金：

中国国家自然科学基金;

关键词：

starfish-derived fungus; Penicillium sp; citrinin dimers; antifungal activities; cytotoxic activities; protein-protein interaction network; IN-VITRO; DERIVATIVES; COMPOUND; GROWTH;

D O I：

10.3390/md20070443

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel, rare carbon-bridged citrinin dimers, namely dicitrinones G-J (1-4), and five known analogs (5-9) were isolated from the starfish-derived fungus Penicillium sp. GGF 16-1-2. Their structures were elucidated by extensive spectroscopic analysis and quantum chemical calculations. Compounds 1-9 exhibited strong antifungal activities against Colletotrichum gloeosporioides with LD50 values from 0.61 mu g/mL to 16.14 mu g/mL. Meanwhile, all compounds were evaluated for their cytotoxic activities against human pancreatic cancer BXPC-3 and PANC-1 cell lines; as a result, compound 1 showed more significant cytotoxicities than the positive control against both cell lines. In addition, based on the analyses of the protein-protein interaction (PPI) network and Western blot, 1 could induce apoptosis by activating caspase 3 proteins (CASP3).

引用

页数：12

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