Role of islet β cell autophagy in the pathogenesis of diabetes

被引：82
作者：
Lee, Myung-Shik [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
beta cell; autophagy; obesity; ER stress; islet amyloid; ENDOPLASMIC-RETICULUM STRESS; AMYLOID POLYPEPTIDE TOXICITY; REGULATED AUTOPHAGY; NLRP3; INFLAMMASOME; OXIDATIVE STRESS; PROTECTIVE ROLE; ER STRESS; RAT-LIVER; INSULIN; ACTIVATION;
D O I：
10.1016/j.tem.2014.08.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
While the role of autophagy in the physiology of endocrine organs and the development of metabolic disorders or diabetes has been investigated, the relationship between the pancreatic islet and autophagy has not been explored extensively. In this review, studies on the possible involvement of dysregulated autophagy in the pathogenesis of metabolic syndrome and diabetes will be summarized with an emphasis on the autophagic process in pancreatic islet cells. Novel findings regarding the role of autophagy in human beta cell pathology and the development of type 2 diabetes (T2D) characterized by islet amyloid deposition will be discussed. Careful design of agents enhancing autophagic activity in beta cells might serve as a novel approach towards therapeutics for the treatment of diabetes.
引用
收藏
页码：620 / 627
页数：8
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