Basics of Intra-arterial Y-90 Microsphere Therapy for Liver Tumors: Part I

Intra-arterial yttrium-90 (Y-90) microsphere therapy is a radionuclide therapy in which therapeutic radiation-loaded microspheres are targeted to microvasculature of hepatic tumors through arterial administration. The conceptual basis of this therapy depends primarily on the unique preferential blood supply of tumor cells versus healthy hepatocytes in the liver.