Prevention of chemotherapy-induced ovarian damage

被引：105
作者：
Roness, Hadassa [1 ]
Kashi, Oren [1 ]
Meirow, Dror [1 ]
机构：
[1] Chaim Sheba Med Ctr, Ctr Fertil Preservat, IL-52621 Tel Hashomer, Israel
来源：
FERTILITY AND STERILITY | 2016年 / 105卷 / 01期
关键词：
Fertility preservation; chemotherapy; follicle activation; COLONY-STIMULATING FACTOR; ANTI-MULLERIAN HORMONE; PROTECTS MOUSE OOCYTES; ABL TYROSINE KINASE; FERTILITY PRESERVATION; INDUCED APOPTOSIS; GNRH AGONIST; DNA-DAMAGE; C-ABL; TISSUE CRYOPRESERVATION;
D O I：
10.1016/j.fertnstert.2015.11.043
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic drugs on the ovary have opened up new directions for the protection of the ovary from chemotherapy-induced damage. These advances have spurred the investigation of pharmacological agents to prevent ovarian damage at the time of treatment. Prevention of ovarian damage and follicle loss would provide significant advantages over existing fertility preservation techniques. This manuscript reviews new methods for the prevention of chemotherapy-induced ovarian damage, including agents that act on the PI3K/PTEN/Akt follicle activation pathway, apoptotic pathways, the vascular system, and other potential methods of reducing chemotherapy-induced ovotoxicity. (C) 2016 by American Society for Reproductive Medicine.
引用
收藏
页码：20 / 29
页数：10
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