Temperature sensing and bio-imaging applications based on polyethylenimine/CaF2 nanoparticles with upconversion fluorescence

被引:36
作者
Liu, Guofeng [1 ]
Sun, Zhen [1 ]
Fu, Zuoling [1 ]
Ma, Li [2 ]
Wang, Xiaojun [2 ]
机构
[1] Jilin Univ, Coherent Light & Atom & Mol Spect Lab, Key Lab Phys & Technol Adv Batteries, Coll Phys, Changchun 130012, Peoples R China
[2] Georgia Southern Univ, Dept Phys, Statesboro, GA 30458 USA
关键词
Optical temperature sensors; Nano-thermometry; Bio-imaging; LUMINESCENCE PROPERTIES; DOPED CAF2; NANOCRYSTALS; YB3+; THERMOMETRY; EXCITATION; EMISSION; BEHAVIOR;
D O I
10.1016/j.talanta.2017.03.054
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Rare earth ion-doped upconversion nanoparticles (UCNPs) have become a research hotspot for their applications such as nano-thermometry and bio-imaging. Here we report one pot solvothermal synthesis of polyethylenimine (PEI) coated CaF2: 1%Er3+, 2%Yb3+ UCNPs with good water-solubility and biocompatibility. The nanoparticles show a spherical shape with an average size of 40 nm and display intense green light (Yb3+ and Er3+) under the 980 nm irradiation. The maximum sensitivity of temperature sensing in the biological temperature range is obtained to be 0.00215 K-1 using the fluorescence intensity ratio (FIR) technique. Furthermore, after the UCNPs are incubated with Hela cancer cells for 6 h, the obvious green sign from Er3+ can be observed under the excitation at 980 nm. All the experimental results imply that the PEI/CaF2: 1%Er3+, 2% Yb3+ nanoparticles are excellent candidates for nano-thermometry and have good potential for biological applications.
引用
收藏
页码:181 / 188
页数:8
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