A Neurobehavioral Intervention and Assessment Program in Very Low Birth Weight Infants: Outcome at 24 Months

被引:66
作者
Koldewijn, Karen [1 ]
van Wassenaer, Aleid [2 ]
Wolf, Marie-Jeanne [1 ,2 ]
Meijssen, Dominique [3 ]
Houtzager, Bregje [2 ]
Beelen, Anita [1 ]
Kok, Joke [2 ]
Nollet, Frans [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Rehabil, NL-1100 DD Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Neonatol, NL-1100 DD Amsterdam, Netherlands
[3] Tilburg Univ, Dept Pediat Psychol, NL-5000 LE Tilburg, Netherlands
关键词
BEHAVIORAL-ASSESSMENT; PRETERM CHILDREN; SUPPORT; MOTHER; TRIAL;
D O I
10.1016/j.jpeds.2009.09.009
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To determine whether the Infant Behavioral Assessment and Intervention Program (IBAIP) improves development and behavior in very low birth weight (VLBW) infants at 24-month corrected age. Study design In a multicenter, randomized, controlled trial 86 infants received postdischarge intervention until 6-month corrected age. The intervention consisted of supporting infants' self-regulation and development, and facilitating sensitive parent-infant interactions; 90 control infants received regular care. At 6 months, positive intervention effects were found. At 24 months, development and behavior were evaluated with the Bayley Scales of Infant Development-II (BSID-II) and the Child Behavior Check List (CBCL). Results Eighty-three intervention and 78 control infants were available for follow-up. After adjustment for differences in perinatal characteristics, an intervention effect of 6.4 points (+/- standard error, 2.4) on the Psychomotor Developmental Index favored the intervention infants. Groups did not differ on the Mental Developmental Index, the Behavioral Rating Scale of the BSID-II, or on the CBCL. Subgroup analyses revealed improved motor as well as improved mental outcomes in intervention infants with bronchopulmonary dysplasia and with combined biological and social risk factors. Conclusions The IBAIP shows sustained motor improvement in VLBW infants until 2-year corrected age. (J Pediatr 2010;156:359-65).
引用
收藏
页码:359 / 365
页数:7
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