Recent progress toward the total synthesis of humulanolides

被引：11
作者：
Han, Jing-Chun [1 ,3 ]
Liu, Xin [1 ,2 ]
Zhao, Jing [2 ]
Li, Shaoping [2 ]
Li, Chuang-Chuang [1 ]
机构：
[1] South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Peoples R China
[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
[3] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 24期
关键词：
Natural products; Humulanolide; Asteriscanolide; Total synthesis; SESQUITERPENE LACTONE; ENE-VINYLCYCLOPROPANES; HUMULENE DERIVATIVES; COLLECTIVE SYNTHESIS; 5+2+1 CYCLOADDITION; ASTERISCUNOLIDE-D; NATURAL-PRODUCTS; RING FORMATION; METATHESIS; ASTERISCANOLIDE;
D O I：
10.1016/j.tet.2017.05.009
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The humulanolides are a series of sesquiterpene lactones, most of which have unique and challenging structure. The humulanolides have exhibited anticancer activity. The combinations of fascinating structural motifs and promising pharmacological properties have prompted significant interest in the synthetic community. In this review, we provide a summary of recent progress regarding the total synthesis of humulanolides. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3289 / 3303
页数：15
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