Organometallic binuclear Pd(II) complex: Synthesis, crystal structure and in-vitro antitumor activity study

被引：7

作者：

Gong, Guidong ^{[1
]}

Gao, Xingxing ^{[1
]}

Yu, Xianhong ^{[1
]}

Zhang, Huiya ^{[1
]}

Yang, Jiaqi ^{[1
]}

Zhang, Zhonghui ^{[1
]}

Du, Guoyuan ^{[1
]}

Cao, Yuan ^{[1
]}

Zhao, Gang ^{[1
]}

机构：

[1] Sichuan Univ, Sch Chem Engn, Chengdu 610064, Sichuan, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2019年 / 105卷

关键词：

Planar chiral; Ferrocene Cyclopalladated compound; Crystal structure; Antitumor activity; PERMEABILIZATION; PALLADACYCLE; APOPTOSIS; DRUGS; RING;

D O I：

10.1016/j.inoche.2019.05.017

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel planar chiral ferrocene cyclopalladated compound (C2) was synthesized and fully characterized. The absolute configuration of C2 has been determined by single-crystal X-ray analysis. The cytotoxic activities of C2 and cisplatin were evaluated against liver (MHCC97 and HepG2), mouse breast (4 T1) and ovarian granulosa (KGN) cancer cell lines. C2 was about 23 times more potent than cisplatin in the suppression of KGN cells.

引用

页码：199 / 202

页数：4

共 22 条

[1] Cyclopalladated primary amines: A preliminary study of antiproliferative activity through apoptosis induction [J].

Albert, Joan ;

Bosque, Ramon ;

Crespo, Margarita ;

Garcia, Graciela ;

Granell, Jaume ;

Lopez, Concepcion ;

Lovelle, Maria Victoria ;

Qadir, Romana ;

Gonzalez, Asensio ;

Jayaraman, Anusha ;

Mila, Enric ;

Cortes, Roldan ;

Quirante, Josefina ;

Calvis, Carme ;

Messeguer, Ramon ;

Badia, Josefa ;

Baldoma, Laura ;

Cascante, Marta .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 84 :530-536

[2] A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity [J].

Albert, Joan ;

Bosque, Ramon ;

Cadena, Magali ;

D'Andrea, Lucia ;

Granell, Jaume ;

Gonzalez, Asensio ;

Quirante, Josefina ;

Calvis, Carmen ;

Messeguer, Ramon ;

Badia, Josefa ;

Baldoma, Laura ;

Calvet, Teresa ;

Font-Bardia, Merce .

ORGANOMETALLICS, 2014, 33 (11) :2862-2873

[3] Cyclopalladated benzophenone imines: Synthesis, cytotoxicity against human breast adenocarcinoma cell lines and DNA interaction [J].

Albert, Joan ;

Garcia, Silvia ;

Granell, Jaume ;

Llorca, Albert ;

Victoria Lovelle, Maria ;

Moreno, Virtudes ;

Presa, Andreu ;

Rodriguez, Laura ;

Quirante, Josefina ;

Calvis, Carme ;

Messeguer, Ramon ;

Badia, Josefa ;

Baldoma, Laura .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 724 :289-296

[4] Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells [J].

Barbosa, Christiano M. V. ;

Oliveira, Carlos R. ;

Nascimento, Fabio D. ;

Smith, Mickaela C. M. ;

Fausto, Damela M. ;

Soufen, Marco Antonio ;

Sena, Eliana ;

Araujo, Ronaldo C. ;

Tersariol, Ivarne L. S. ;

Bincoletto, Claudia ;

Caires, Antonio C. F. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 542 (1-3) :37-47

[5] A 25-Year Experience of US Food and Drug Administration Accelerated Approval of Malignant Hematology and Oncology Drugs and Biologics A Review [J].

Beaver, Julia A. ;

Howie, Lynn J. ;

Pelosof, Lorraine ;

Kim, Tamy ;

Liu, Jinzhong ;

Goldberg, Kirsten B. ;

Sridhara, Rajeshwari ;

Blumenthal, Gideon M. ;

Farrell, Ann T. ;

Keegan, Patricia ;

Pazdur, Richard ;

Kluetz, Paul G. .

JAMA ONCOLOGY, 2018, 4 (06) :849-856

[6] Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities [J].

Chopra, Rakesh ;

de Kock, Carmen ;

Smith, Peter ;

Chibale, Kelly ;

Singh, Kamaljit .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 100 :1-9

[7] Platinum-based drugs: past, present and future [J].

Dilruba, Shahana ;

Kalayda, Ganna V. .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 77 (06) :1103-1124

[8] Organoids in cancer research [J].

Drost, Jarno ;

Clevers, Hans .

NATURE REVIEWS CANCER, 2018, 18 (07) :407-418

[9] Assessment of the antitumor activity of a cyclopalladated ferrocene compound assisted by a dual-targeting drug delivery system [J].

Gong, Guidong ;

Cao, Yuan ;

Qian, Hongyun ;

Zhou, Yangyang ;

Zhao, Haihang ;

Li, Ling ;

Wang, Fei ;

Zhao, Gang .

CHEMICAL COMMUNICATIONS, 2018, 54 (60) :8312-8315

[10] Planar Chiral Ferrocene Cyclopalladated Derivatives Induce Caspase-Dependent Apoptosis and Antimetastasis in Cancer Cells [J].

Gong, Guidong ;

Cao, Yuan ;

Wang, Fei ;

Zhao, Gang .

ORGANOMETALLICS, 2018, 37 (07) :1103-1113

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