ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR IN SJOGREN'S SYNDROME

被引:0
作者
Barcelos, Filipe [1 ]
Abreu, Isabel [2 ]
Patto, Jose Vaz [1 ]
Trindade, Helder [2 ]
Teixeira, Ana [1 ]
机构
[1] Portuguese Inst Rheumatol, Lisbon, Portugal
[2] Fac Med Sci, Dept Immunol, Lisbon, Portugal
来源
ACTA REUMATOLOGICA PORTUGUESA | 2009年 / 34卷 / 04期
关键词
Sjogren's Syndrome; Anti-CCP Antibodies; Rheumatoid Factors; Rheumatoid Arthritis; CLINICAL-SIGNIFICANCE; ELISA ASSAYS; ARTHRITIS; AUTOANTIBODIES; IGM; PREVALENCE; DISEASE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: The purpose of this study was to evaluate the prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies (anti-CCP-Abs), IgM and IgA rheumatoid factors (RFs) in primary Sjogren's Syndrome (pSS). Materials and Methods:We compared clinical and serological. characteristics of 31 pSS and 31 Rheumatoid Arthritis (RA) patients. Both, anti-CCP-Abs and RFs (IgM, IgA) directed against Fc determinants of IgG from humans and rabbit were detected by enzyme-linked immunosorbent assay (ELISA). We included 31 blood donors as control group for the evaluation of RFs and anti-CCP-Abs. Nine (29%) pSS patients presented arthritis, and 10 (32,3%) RA patients also had secondary Sjogren's syndrome (sSS) Results: IgM and IgA RFs prevalence was similar in pSS and RA, whichever the antigene (Human or Rabbit IgG) used. However, RA patients with sSS showed a tendency to present more often RF positivity, longer disease duration and higher ESR and CRP when compared with pSS patients with arthritis. Anti-CCP-Abs were detected in 64,5% of RA patients and in only 6,9% of pSS patients (p<0,0005). Anti-CCP-Abs were more often positive in RA patients with sSS (RA/sSS) (8 patients, 80%) than in RA patients without sSS (18 patients, 58,1%), and were absent in pSS patients with arthritis. RF-positive pSS patients presented more often pulmonary involvement and higher inflammatory parameters, and less often neuropathy compared to RF-negative patients. In controls, anti-CCP-Abs were absent and REs were negligible. Conclusions: Anti-CCP-Abs were detected in only a few pSS patients, none of whom presented arthritis, which contrasts with the high frequency of these antibodies in RA/sSS. These results suggest that anti-CCP-Abs could be useful in the distinction between pSS and RA with sSS. Although not useful for the differential diagnosis between RA and pSS, RFs may have a prognostic role in pSS.
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页码:608 / 612
页数:5
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