Doses and models in risk assessment analysis for bronchial hyperresponsiveness

被引:5
作者
de Marco, R [1 ]
Bugiani, M
Zanolin, E
Verlato, G
Rijcken, B
机构
[1] Univ Verona, Cattedra Stat Med & Biometria, Policlin Borgo Roma, I-37134 Verona, Italy
[2] Ist Fisiopatol Resp, Dispensario Igiene Sociale, Turin, Italy
[3] Univ Groningen, Dept Epidemiol, Groningen, Netherlands
关键词
bronchial hyperreactivity; survival models; methacholine; provocation test; asthma surveys; model fit;
D O I
10.1016/S0895-4356(97)00222-9
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
The aims of this study are: (1) to evaluate whether the estimates of the association of risk factors with bronchial hyperresponsiveness (BHR) depends on the accumulated dose administered in challenge tests; and (2) to verify whether a model developed for survival studies (Weibull regression) is suited to analyze methacholine dose-response curves. For these purposes, 863 challenge tests, from EC Respiratory Health Survey in Italy, up to a cumulative dose of 6 mg methacholine, were analyzed by Weibull regression and by traditional methods (logistic model and linear model), both before and after truncation of the curves at 2 mg. With all methods the main risk factors for BHR were respiratory symptoms and atopy while age and airway caliber exerted a protective action. Our results confirmed that in epidemiological surveys 2 mg methacholine is enough to fully appreciate the effect of risk factors on BHR and showed chat the Weibull model explains the observed variability better than linear and logistic regressions. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:19 / 28
页数:10
相关论文
共 44 条
[1]   ANALYSIS OF BRONCHIAL REACTIVITY IN EPIDEMIOLOGIC STUDIES [J].
ABRAMSON, MJ ;
SAUNDERS, NA ;
HENSLEY, MJ .
THORAX, 1990, 45 (12) :924-929
[2]  
AITKIN M, 1989, J STAT MODELLING GLI
[3]   REGRESSION-ANALYSIS OF GROUPED SURVIVAL-DATA - INFORMATIVE CENSORING AND DOUBLE SAMPLING [J].
BAKER, SG ;
WAX, Y ;
PATTERSON, BH .
BIOMETRICS, 1993, 49 (02) :379-389
[4]  
Blossfeld H.P., 1989, Event History Analysis. Statistical Theory and Application in the Social Sciences
[5]  
BRITTON J, 1994, EUR RESPIR J, V7, P881
[6]   DESCRIPTIVE EPIDEMIOLOGY OF BRONCHIAL REACTIVITY IN AN ADULT-POPULATION - RESULTS FROM A COMMUNITY STUDY [J].
BURNEY, PGJ ;
BRITTON, JR ;
CHINN, S ;
TATTERSFIELD, AE ;
PAPACOSTA, AO ;
KELSON, MC ;
ANDERSON, F ;
CORFIELD, DR .
THORAX, 1987, 42 (01) :38-44
[7]   THE EUROPEAN-COMMUNITY-RESPIRATORY-HEALTH-SURVEY [J].
BURNEY, PGJ ;
LUCZYNSKA, C ;
CHINN, S ;
JARVIS, D ;
VERMEIRE, P ;
DAHL, R ;
NIELSEN, N ;
MAGNUSSEN, H ;
WICHMANN, H ;
PAPAGEORGIOU, N ;
ANTO, J ;
CAPELASTEGUI, A ;
CASTILLO, J ;
MALDONADO, J ;
MORATALLA, J ;
QUIROS, R ;
BOUSQUET, J ;
NEUKIRCH, F ;
PIN, I ;
TAYTARD, A ;
TECULESCU, D ;
PRICHARD, J ;
BUGIANI, M ;
DEMARCO, R ;
CASCIO, VL ;
RIJCKEN, B ;
AVILA, R ;
LOUREIRO, C ;
MARQUES, A ;
BURR, M ;
HALL, R ;
HARRISON, B ;
STARK, J ;
FLOREY, C ;
POPP, W ;
GISLASON, T ;
GULSVIK, A ;
ACKERMANNLIEBRICH, U ;
LINDHOLM, N ;
BOMAN, G ;
ROSENHALL, L ;
AITKHALED, N ;
ABRAMSON, M ;
MANFREDA, J ;
CHOWGULE, R ;
CRANE, J ;
STEPANOV, I ;
BUIST, S .
EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (05) :954-960
[8]   RELATIONSHIPS OF BRONCHIAL RESPONSIVENESS ASSESSED BY METHACHOLINE TO SERUM IGE, LUNG-FUNCTION, SYMPTOMS, AND DIAGNOSES IN 11-YEAR-OLD NEW-ZEALAND CHILDREN [J].
BURROWS, B ;
SEARS, MR ;
FLANNERY, EM ;
HERBISON, GP ;
HOLDAWAY, MD .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1992, 90 (03) :376-385
[9]   DISTRIBUTION OF BRONCHIAL NONSPECIFIC REACTIVITY IN THE GENERAL-POPULATION [J].
CERVERI, I ;
BRUSCHI, C ;
ZOIA, MC ;
ZANON, P ;
MACCARINI, L ;
GRASSI, M ;
RAMPULLA, C .
CHEST, 1988, 93 (01) :26-30
[10]  
CHINN S, 1993, EUR RESPIR J, V6, P670