Factors Associated With Long-term Intraocular Pressure Fluctuation in Primary Angle Closure Disease: The CUHK PACG Longitudinal (CUPAL) Study

被引:9
作者
Cheung, Carol Y. [1 ]
Li, Sophia Ling [1 ]
Chan, Noel [2 ]
Wong, Mandy Oi-Man [2 ]
Chan, Poemen Pui-Man [2 ]
Lai, Isabel [2 ]
Baig, Nafees [2 ]
Tan, Shaoying [1 ]
Man, Xiaofei [1 ]
Tang, Fangyao [1 ]
Wang, Yu Meng [1 ]
Tham, Clement C. [1 ,2 ]
机构
[1] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, 4-F Hong Kong Eye Hosp,147K Argyle St, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Eye Hosp, Hong Kong, Hong Kong, Peoples R China
关键词
long-term IOP; IOP fluctuation; affecting factors; PACD; VISUAL-FIELD PROGRESSION; ADVANCED GLAUCOMA INTERVENTION; COMBINED PHACOTRABECULECTOMY; RISK-FACTOR; PHACOEMULSIFICATION; TRABECULECTOMY; PREVALENCE; TRIAL; DETERMINANTS; POPULATION;
D O I
10.1097/IJG.0000000000000996
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To determine the demographic, ocular, and systemic factors associated with long-term intraocular pressure (IOP) fluctuation in primary angle closure disease (PACD). Methods: This prospective cohort study included 422 PACD eyes from 269 Chinese patients, including 274 primary angle closure glaucoma (PACG) eyes and 152 primary angle closure/primary angle closure suspect (PAC/PACS) eyes. Long-term IOP fluctuation defined as the SD of all IOP measurements over 2 years (at least 5 measurements in total). Chinese patients with PACD were recruited and followed up 3 monthly. Eyes with IOP-lowering surgery or lens extraction performed within the 2-year study period were excluded. Patient demographics, received treatments, ocular biometry, retinal nerve fiber layer thickness, and systemic factors (eg, hypertension, smoking) were evaluated. Generalized estimating equations adjusting for inter-eye correlation were used to determine the associations. Results: Eyes with PACG had significantly higher IOP fluctuation than PAC/PACS (2.4 +/- 1.2 versus 2.1 +/- 0.9 mm Hg; P = 0.04). In the multivariate analysis with PACG eyes, higher baseline IOP (P < 0.001), greater number of IOP-lowering medications (P < 0.001), previous trabeculectomy (P = 0.002), and current smoking (P = 0.03) were significantly associated with larger IOP fluctuation, whereas diabetes mellitus was associated with lower IOP fluctuation (P = 0.03). Among PAC/PACS eyes, younger age group (P < 0.001), male sex (P = 0.002), and higher baseline IOP (P < 0.001) were significantly associated with larger IOP fluctuation. Conclusions: PACG eyes have greater IOP fluctuation than PAC/PACS eyes. Certain demographic, ocular, and systemic factors are associated with IOP fluctuation in PACD eyes.
引用
收藏
页码:703 / 710
页数:8
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