A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines

被引：13
作者：
Ducray, Richard [1 ]
Boutron, Pascal [1 ]
Didelot, Myriam [1 ]
Germain, Herve [1 ]
Lach, Franck [1 ]
Lamorlette, Maryannick [1 ]
Legriffon, Antoine [1 ]
Maudet, Mickael [1 ]
Menard, Morgan [1 ]
Pasquet, Georges [1 ]
Renaud, Fabrice [1 ]
Simpson, Iain [2 ]
Young, Gail L. [2 ]
机构：
[1] AstraZeneca, Res Ctr, ZI Pompelle, F-51689 Reims 2, France
[2] AstraZeneca, Canc Med Chem, Macclesfield SK10 4TG, Cheshire, England
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 36期
关键词：
IMIDAZOPYRIDINE ANTICOCCIDIAL AGENTS; DEPENDENT KINASE INHIBITORS; BIOLOGICAL-ACTIVITY; SELECTIVE CLASS; POTENT ACTIVITY; PART II; SAR; HERPESVIRUSES; OPTIMIZATION; DERIVATIVES;
D O I：
10.1016/j.tetlet.2010.07.024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A two-step synthesis of 3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridines is presented. The late stage elaboration of the imidazopyridine through a cyclocondensation allows a rapid access to a variety of substitution patterns. The intermediate enol ethers were obtained from inexpensive reagents in a ligand-free Heck coupling. This methodology has been extended to the formation of pyrazolo[1,5-a]pyridines via a formal 1,3-dipolar cycloaddition. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：4755 / 4758
页数：4
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