Fourier-domain low-coherence interferometry for light-scattering spectroscopy

被引：80
作者：
Wax, A [1 ]
Yang, CH
Izatt, JA
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Fitzpatrick Ctr Photon, Durham, NC 27708 USA
来源：
OPTICS LETTERS | 2003年 / 28卷 / 14期
关键词：
D O I：
10.1364/OL.28.001230
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic-scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1-mum depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed. (C) 2003 Optical Society of America.
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收藏
页码：1230 / 1232
页数：3
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