Fourier-domain low-coherence interferometry for light-scattering spectroscopy

被引：80

作者：

Wax, A ^{[1
]}

Yang, CH

Izatt, JA

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[2] Duke Univ, Fitzpatrick Ctr Photon, Durham, NC 27708 USA

来源：

OPTICS LETTERS | 2003年 / 28卷 / 14期

关键词：

D O I：

10.1364/OL.28.001230

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic-scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1-mum depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed. (C) 2003 Optical Society of America.

引用

页码：1230 / 1232

页数：3

共 15 条

[1] Detection of preinvasive cancer cells [J].

Backman, V ;

Wallace, MB ;

Perelman, LT ;

Arendt, JT ;

Gurjar, R ;

Müller, MG ;

Zhang, Q ;

Zonios, G ;

Kline, E ;

McGillican, T ;

Shapshay, S ;

Valdez, T ;

Badizadegan, K ;

Crawford, JM ;

Fitzmaurice, M ;

Kabani, S ;

Levin, HS ;

Seiler, M ;

Dasari, RR ;

Itzkan, I ;

Van Dam, J ;

Feld, MS .

NATURE, 2000, 406 (6791) :35-36

[2] Measuring cellular structure at submicrometer scale with light scattering spectroscopy [J].

Backman, V ;

Gopal, V ;

Kalashnikov, M ;

Badizadegan, K ;

Gurjar, R ;

Wax, A ;

Georgakoudi, I ;

Mueller, M ;

Boone, CW ;

Dasari, RR ;

Feld, MS .

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2001, 7 (06) :887-893

[3] Spectral resolution and sampling issues in Fourier-transform spectral interferometry [J].

Dorrer, C ;

Belabas, N ;

Likforman, JP ;

Joffre, M .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 2000, 17 (10) :1795-1802

[4] Trimodal spectroscopy for the detection and characterization of cervical precancers in vivo [J].

Georgakoudi, I ;

Sheets, EE ;

Müller, MG ;

Backman, V ;

Crum, CP ;

Badizadegan, K ;

Dasari, RR ;

Feld, MS .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (03) :374-382

[5]

KULKARNI MD, 1996, 1996 OSA TECHNICAL D, V9, P59

[6] Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography [J].

Leitgeb, R ;

Wojtkowski, M ;

Kowalczyk, A ;

Hitzenberger, CK ;

Sticker, M ;

Fercher, AF .

OPTICS LETTERS, 2000, 25 (11) :820-822

[7] Spectroscopic optical coherence tomography [J].

Morgner, U ;

Drexler, W ;

Kärtner, FX ;

Li, XD ;

Pitris, C ;

Ippen, EP ;

Fujimoto, JG .

OPTICS LETTERS, 2000, 25 (02) :111-113

[8] Light scattering from cells: the contribution of the nucleus and the effects of proliferative status [J].

Mourant, JR ;

Canpolat, M ;

Brocker, C ;

Esponda-Ramos, O ;

Johnson, TM ;

Matanock, A ;

Stetter, K ;

Freyer, JP .

JOURNAL OF BIOMEDICAL OPTICS, 2000, 5 (02) :131-137

[9] Cellular organization and substructure measured using angle-resolved low-coherence interferometry [J].

Wax, A ;

Yang, CH ;

Backman, V ;

Badizadegan, K ;

Boone, CW ;

Dasari, RR ;

Feld, MS .

BIOPHYSICAL JOURNAL, 2002, 82 (04) :2256-2264

[10] Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometry [J].

Wax, A ;

Yang, CH ;

Backman, V ;

Kalashnikov, M ;

Dasari, RR ;

Feld, MS .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2002, 19 (04) :737-744

← 1 2 →