Anti-inflammatory treatments for stroke: from bench to bedside

被引:72
作者
Drieu, Antoine [1 ]
Levard, Damien [1 ]
Vivien, Denis [1 ,2 ]
Rubio, Marina [1 ]
机构
[1] Normandy Univ, Pathophysiol & Imaging Neurol Disorders, Blvd Henri Becquerel BP 5229, F-14000 Caen, France
[2] CHU Caen, Imaging Neurol Disorders, Caen, France
关键词
clinical trial; immunomodulatory drugs; inflammation; stroke models; translation; ACUTE ISCHEMIC-STROKE; REGULATORY T-CELLS; FOCAL CEREBRAL-ISCHEMIA; SPINAL-CORD-INJURY; INTERLEUKIN-1 RECEPTOR ANTAGONIST; IMMUNE MODULATOR FINGOLIMOD; SENSITIVE MOLECULAR MRI; CENTRAL-NERVOUS-SYSTEM; REDUCES BRAIN-DAMAGE; THROMBOEMBOLIC STROKE;
D O I
10.1177/1756286418789854
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
So far, intravenous tissue-type plasminogen activator (tPA) and mechanical removal of arterial blood clot (thrombectomy) are the only available treatments for acute ischemic stroke. However, the short therapeutic window and the lack of specialized stroke unit care make the overall availability of both treatments limited. Additional agents to combine with tPA administration or thrombectomy to enhance efficacy and improve outcomes associated with stroke are needed. Stroke-induced inflammatory processes are a response to the tissue damage due to the absence of blood supply but have been proposed also as key contributors to all the stages of the ischemic stroke pathophysiology. Despite promising results in experimental studies, inflammation-modulating treatments have not yet been translated successfully into the clinical setting. This review will (a) describe the timing of the stroke immune pathophysiology; (b) detail the immune responses to stroke sift-through cell type; and (c) discuss the pitfalls on the translation from experimental studies to clinical trials testing the therapeutic pertinence of immune modulators.
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页数:15
相关论文
共 125 条
[1]   Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging [J].
Albers, G. W. ;
Marks, M. P. ;
Kemp, S. ;
Christensen, S. ;
Tsai, J. P. ;
Ortega-Gutierrez, S. ;
McTaggart, R. A. ;
Torbey, M. T. ;
Kim-Tenser, M. ;
Leslie-Mazwi, T. ;
Sarraj, A. ;
Kasner, S. E. ;
Ansari, S. A. ;
Yeatts, S. D. ;
Hamilton, S. ;
Mlynash, M. ;
Heit, J. J. ;
Zaharchuk, G. ;
Kim, S. ;
Carrozzella, J. ;
Palesch, Y. Y. ;
Demchuk, A. M. ;
Bammer, R. ;
Lavori, P. W. ;
Broderick, J. P. ;
Lansberg, M. G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (08) :708-718
[2]  
[Anonymous], 2010, INFLAMMATION MICROCI
[3]   Systematic Review and Stratified Meta-analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke [J].
Banwell, Victoria ;
Sena, Emily S. ;
Macleod, Malcolm R. .
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2009, 18 (04) :269-276
[4]   Antibody to the α4 integrin decreases infarct size in transient focal cerebral ischemia in rats [J].
Becker, K ;
Kindrick, D ;
Relton, J ;
Harlan, J ;
Winn, R .
STROKE, 2001, 32 (01) :206-211
[5]  
Bednar MM, 1998, NEUROL RES, V20, P403
[6]   MONOCLONAL-ANTIBODIES PREVENTING LEUKOCYTE ACTIVATION REDUCE EXPERIMENTAL NEUROLOGIC INJURY AND ENHANCE EFFICACY OF THROMBOLYTIC THERAPY [J].
BOWES, MP ;
ROTHLEIN, R ;
FAGAN, SC ;
ZIVIN, JA .
NEUROLOGY, 1995, 45 (04) :815-819
[7]   Control of microglial neurotoxicity by the fractalkine receptor [J].
Cardona, Astrid E. ;
Pioro, Erik P. ;
Sasse, Margaret E. ;
Kostenko, Volodymyr ;
Cardona, Sandra M. ;
Dijkstra, Ineke M. ;
Huang, DeRen ;
Kidd, Grahame ;
Dombrowski, Stephen ;
Dutta, RanJan ;
Lee, Jar-Chi ;
Cook, Donald N. ;
Jung, Steffen ;
Lira, Sergio A. ;
Littman, Dan R. ;
Ransohoff, Richard M. .
NATURE NEUROSCIENCE, 2006, 9 (07) :917-924
[8]   Sterile inflammation: sensing and reacting to damage [J].
Chen, Grace Y. ;
Nunez, Gabriel .
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (12) :826-837
[9]   GLUTAMATE NEUROTOXICITY IN CORTICAL CELL-CULTURE IS CALCIUM DEPENDENT [J].
CHOI, DW .
NEUROSCIENCE LETTERS, 1985, 58 (03) :293-297
[10]   Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia [J].
Chu, Hannah X. ;
Kim, Hyun A. H. ;
Lee, Seyoung ;
Moore, Jeffrey P. ;
Chan, Christopher T. ;
Vinh, Antony ;
Gelderblom, Mathias ;
Arumugam, Thiruma V. ;
Broughton, Brad R. S. ;
Drummond, Grant R. ;
Sobey, Christopher G. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2014, 34 (03) :450-459