Inhibitory effects of 2′-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation

被引：0
|
作者：
Lim, SS
Jung, SH
Ji, J
Shin, KH
Keum, SR
机构：
[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul, South Korea
[2] Korea Univ, Dept Chem, Seoul, South Korea
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2000年 / 48卷 / 11期
关键词：
5 '-chloro-3,2 '-dihydroxychalcone; rat lens aldose reductase; platelet aggregation; diabetic complication;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications, 5'-chloro-1,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 mug/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
引用
收藏
页码：1786 / 1789
页数：4
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