Sonodynamically-induced cell damage with fluorinated anthracycline derivative, FAD104

被引：18
|
作者：
Yumita, N
Umemura, S
Kaneuchi, M
Okano, Y
Magario, N
Ishizaki, M
Shimizu, K
Sano, Y
Umemura, K
Nishigaki, R
机构：
[1] Hitachi Ltd, Cent Res Lab, Kokubunji, Tokyo 185, Japan
[2] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 274, Japan
来源：
CANCER LETTERS | 1998年 / 125卷 / 1-2期
关键词：
ultrasound; cell damage; anthracycline derivative; sarcoma; 180; sonochemical mechanism;
D O I：
10.1016/S0304-3835(97)00515-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 mu M FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism. Published by Elsevier Science Ireland Ltd.
引用
收藏
页码：209 / 214
页数：6
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