Melanoma of the lower genital tract: Prognostic factors and treatment modalities

被引：62

作者：

Gadducci, Angiolo ^{[1
]}

Carinelli, Silvestro ^{[2
]}

Guerrieri, Maria Elena ^{[1
]}

Aletti, Giovanni Damiano ^{[3
]}

机构：

[1] Univ Pisa, Div Obstet & Gynecol, Dept Clin & Expt Med, Via Roma 56, I-56127 Pisa, Italy

[2] European Inst Oncol, Div Pathol & Lab Med, Milan, Italy

[3] Univ Milan, European Inst Oncol, Dept Gynecol Surg, Milan, Italy

来源：

GYNECOLOGIC ONCOLOGY | 2018年 / 150卷 / 01期

关键词：

Melanoma; Vulva; Vagina; Cervix; Surgery; Target therapy; PRIMARY MALIGNANT-MELANOMA; PRIMARY VAGINAL MELANOMA; POPULATION-BASED INCIDENCE; VULVAR MELANOMA; MUCOSAL MELANOMAS; CLINICOPATHOLOGICAL ANALYSIS; UTERINE CERVIX; SURVIVAL; CANCER; MANAGEMENT;

D O I：

10.1016/j.ygyno.2018.04.562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary melanomas originating from the gynecological tract are rare and aggressive cancers. The vulva is the most frequent site (70%), followed by vagina and more rarely by cervix. The clinical outcome of patients with female genital tract melanoma is very poor, with a 5-year overall survival (OS) of 37-50% for vulvar, 13-32% for vaginal, and approximately 10% for cervical melanoma. In this systematic review, we analyzed the pathogenesis and the different factors influencing the prognosis of melanomas of the lower genital tract, with particular emphasis on biologic variables that may influence new therapeutic approaches. We evaluated the different treatment modalities described in the literature, in order to offer a possible algorithm that may help the clinicians in diagnosing and treating patients with these uncommon malignancies. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：180 / 189

页数：10

共 73 条

[1] Cytology of Primary Vaginal Melanoma An Unusual Report on Fine Needle Aspiration [J].