Feasibility of radioactive embolization of intracranial aneurysms using 32P-implanted coils

被引：13

作者：

Raymond, J

Leblanc, P

Lambert, A

Georganos, SA

Guilbert, F

Janicki, C

Roorda, S

机构：

[1] Univ Montreal, Ctr Hosp, Dept Radiol, Montreal, PQ H3C 3J7, Canada

[2] Univ Montreal, Ctr Hosp, Res Ctr, Montreal, PQ H3C 3J7, Canada

[3] McGill Univ, Ctr Hlth, Dept Med Phys, Montreal, PQ H3A 2T5, Canada

[4] Univ Montreal, Dept Phys, Montreal, PQ H3C 3J7, Canada

来源：

STROKE | 2003年 / 34卷 / 04期

关键词：

aneurysm; endovascular therapy; radiation;

D O I：

10.1161/01.STR.0000063140.00091.A6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of P-32 per centimeter. Methods-We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 muCi/cm of P-32, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of P-32 in cystic craniopharyngiomas. Results-Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment. Conclusion-Radioactive coil embolization of aneurysms is feasible in most patients.

引用

页码：1035 / 1037

页数：3

共 6 条

[1]

Janicki C, 2002, MED PHYS, V29, P1203

[2]

Piotin M, 2000, AM J NEURORADIOL, V21, P757

[3] In situ beta radiation to prevent recanalization after coil embolization of cerebral aneurysms [J].