Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern -: synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

被引：62
作者：
He, L [1 ]
Chang, HX
Chou, TC
Savaraj, N
Cheng, CC
机构：
[1] Sichuan Univ, W China Sch Pharm, Chengdu 610041, Peoples R China
[2] Univ Kansas, Med Ctr, Drug Dev Lab, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA
[3] Mem Sloan Kettering Canc Ctr, Lab Preclin Pharmacol, New York, NY 10021 USA
[4] Univ Miami, Sch Med, Dept Med, Miami, FL 33136 USA
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 01期
关键词：
2-phenylnaphthalene-type; 11H-indolo[3.2-c]quinoline derivatives; antitumor activity;
D O I：
10.1016/S0223-5234(02)01420-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyclocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码：101 / 107
页数：7
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