TLRs and chronic inflammation

被引：147

作者：

Ospelt, Caroline ^{[1
]}

Gay, Steffen

机构：

[1] Univ Zurich Hosp, Ctr Expt Rheumatol, CH-8091 Zurich, Switzerland

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 04期

关键词：

Innate immunity; TLRs; Chronic inflammation; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; PROINFLAMMATORY GENE-EXPRESSION; ARTHRITIS SYNOVIAL FIBROBLASTS; PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; DORSAL-VENTRAL POLARITY; CENTRAL-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; ACTIVATE B-CELLS;

D O I：

10.1016/j.biocel.2009.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the homeostasis of commensal flora and in the response to stress and danger signals. In this respect, increasing evidence is found that inappropriate quantity or quality of TLR ligands or aberrant response to TLR activation plays a role in a variety of chronic inflammatory diseases. In this review, an overview of the currently known TLRs and their signaling pathways is given and reports about their expression and activation in chronic inflammatory diseases are recapitulated. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：495 / 505

页数：11

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