Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours

被引：9

作者：

Roperto, S. ^{[1
]}

Colabufo, N. A. ^{[2
]}

Inglese, C. ^{[2
]}

Urraro, C. ^{[1
]}

Brun, R. ^{[1
]}

Mezza, E. ^{[3
]}

Staibano, S. ^{[3
]}

Raso, C. ^{[1
]}

Maiolino, P. ^{[1
]}

Russo, V. ^{[1
]}

Palma, E. ^{[4
]}

Roperto, F. ^{[1
]}

机构：

[1] Univ Naples Federico II, Fac Vet Med, Dept Pathol & Anim Hlth, I-80137 Naples, Italy

[2] Univ Bari, Fac Farm, Dipartimento Farmacochim, I-70125 Bari, Italy

[3] Univ Naples Federico II, Dipartimento Sci Biomorfol & Funzionali, I-80137 Naples, Italy

[4] Univ Catanzaro Magna Graecia, Fac Farm, Dipartimento Sci Farmacobiol, I-88100 Catanzaro, Italy

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2010年 / 142卷 / 01期

关键词：

cattle; papillomavirus type-2; sigma-2; ligand; receptor; urothelial tumour; CANCER-CELLS; INDUCED APOPTOSIS; LIPID RAFTS; AUTOPHAGY; PATHWAY; INNATE; TYPE-2; SIGMA-2-RECEPTORS; PATHOPHYSIOLOGY; INHIBITION;

D O I：

10.1016/j.jcpa.2009.06.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The expression of sigma-2 receptors was investigated in nine urothelial tumours of the urinary bladder of cattle. Each tumour was associated with the presence of DNA of bovine papillomavirus type-2 (BPV-2) and expression of the E5 viral oncoprotein. Five tumours were classified as low-grade carcinoma on the basis of morphological criteria and calculation of mean nuclear area (MNA) and mean nuclear perimeter (MNP). Four tumours were classified as high-grade carcinoma. Sigma-2 receptors were overexpressed in both types of carcinoma. In control normal bovine bladder tissue the density of receptors (expressed as the B-max) was 0.37 pmol/mg of protein. Low-grade carcinomas had a mean B-max of 1.37 +/- 0.32 pmol/mg of protein (range 1.03-1.86) and in high-grade carcinomas the mean B-max was 10.9 +/- 2.8 pmol/mg of protein (range 8.2-14). The difference in B-max between low- and high-grade carcinomas was statistically significant (P=0.0001). (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：19 / 26

页数：8

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[1] Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma [J].