Stabilization of Transient 3-Chloroindolenines Enables Diverse Functionalization

被引：9

作者：

Cui, Ranran ^{[1
]}

Ye, Jinxiang ^{[1
]}

Mo, Wenhui ^{[1
]}

Gao, Yu ^{[1
]}

Chen, Haijun ^{[1
]}

机构：

[1] Fuzhou Univ, Fujian Prov Univ, Key Lab Mol Synth & Funct Discovery, Coll Chem, Fuzhou 350116, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

关键词：

C-H AMINATION; TETRAHYDROCARBAZOLES; DERIVATIVES; CARBOLINES; ALKALOIDS; CHEMISTRY; MECHANISM; STRATEGY; RING;

D O I：

10.1021/acs.orglett.9b02920

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transient intermediates as highly reactive species are difficult to manipulate due to their poor stability. Stabilization of unstable intermediates for functionalization is an attractive approach, but the practical applications are still rare. Herein, we explore a strategy that could effectively stabilize labile 3-chloroindolenines and significantly improve the lifetime from seconds to weeks. This chemistry was utilized to enable the synthesis of 55 diverse compounds which are unable to be achieved by traditional approach.

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收藏

页码：8884 / 8887

页数：4

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