Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China

被引：39

作者：

Liu, Jiankui ^{[1
,2
]}

Wei, Chunhua ^{[1
,2
]}

Lin, Zhifeng ^{[3
]}

Xia, Wei ^{[1
,2
]}

Ma, Ying ^{[1
,2
]}

Dai, Ailing ^{[1
,2
]}

Yang, Xiaoyan ^{[1
,2
]}

机构：

[1] Longyan Univ, Coll Life Sci, Longyan, Peoples R China

[2] Longyan Univ, Fujian Prov Key Lab Prevent & Control Anim Infect, Longyan, Peoples R China

[3] Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou, Fujian, Peoples R China

来源：

PEERJ | 2019年 / 7卷

关键词：

PRRSV; Genome sequence; 1-7-4; Molecular characteristic; RESPIRATORY SYNDROME VIRUS; N-LINKED GLYCOSYLATION; EVOLUTIONARY CHARACTERISTICS; NADC30-LIKE STRAIN; ECONOMIC-IMPACT; GP5; RECOMBINATION; EMERGENCE; PATHOGENICITY; ANTIGENICITY;

D O I：

10.7717/peerj.7859

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 17-4. Additionally, FJ0908 had a 100 as deletion (aa329-428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China.

引用

页数：14

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