A common variant on chromosome 9p21 affects the risk of myocardial infarction

被引：1238
作者：
Helgadottir, Anna
Thorleifsson, Gudmar
Manolescu, Andrei
Gretarsdottir, Solveig
Blondal, Thorarinn
Jonasdottir, Aslaug
Jonasdottir, Adalbjorg
Sigurdsson, Asgeir
Baker, Adam
Palsson, Arnar
Masson, Gisli
Gudbjartsson, Daniel F.
Magnusson, Kristinn P.
Andersen, Karl
Levey, Allan I.
Backman, Valgerdur M.
Matthiasdottir, Sigurborg
Jonsdottir, Thorbjorg
Palsson, Stefan
Einarsdottir, Helga
Gunnarsdottir, Steinunn
Gylfason, Arnaldur
Vaccarino, Viola
Hooper, W. Craig
Reilly, Muredach P.
Granger, Christopher B.
Austin, Harland
Rader, Daniel J.
Shah, Svati H.
Quyyumi, Arshed A.
Gulcher, Jeffrey R.
Thorgeirsson, Gudmundur
Thorsteinsdottir, Unnur
Kong, Augustine
Stefansson, Kari
机构：
[1] deCODE Genet, IS-101 Reykjavik, Iceland
[2] Landspitali Univ Hosp, Reykjavik, Iceland
[3] Emory Univ, Sch Med, Atlanta, GA 30322 USA
[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
[5] Duke Univ, Sch Med, Durham, NC 27710 USA
来源：
SCIENCE | 2007年 / 316卷 / 5830期
关键词：
D O I：
10.1126/science.1142842
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction ( MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.
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页码：1491 / 1493
页数：3
相关论文
共 10 条
[1]   Genomic control for association studies [J].
Devlin, B ;
Roeder, K .
BIOMETRICS, 1999, 55 (04) :997-1004
[2]   The regulation of INK4/ARF in cancer and aging [J].
Kim, William Y. ;
Sharpless, Norman E. .
CELL, 2006, 127 (02) :265-275
[3]   Atherosclerosis [J].
Lusis, AJ .
NATURE, 2000, 407 (6801) :233-241
[4]  
MANTEL N, 1959, J NATL CANCER I, V22, P719
[5]   Vascular cell senescence - Contribution to atherosclerosis [J].
Minamino, Tohru ;
Komuro, Issei .
CIRCULATION RESEARCH, 2007, 100 (01) :15-26
[6]  
Samani NJ, 2005, AM J HUM GENET, V77, P1011
[7]   Heart disease and stroke statistics - 2006 update - A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee [J].
Thom, T ;
Haase, N ;
Rosamond, W ;
Howard, VJ ;
Rumsfeld, J ;
Manolio, T ;
Zheng, ZJ ;
Flegal, K ;
O'Donnell, C ;
Kittner, S ;
Lloyd-Jones, D ;
Goff, DC ;
Hong, YL ;
Adams, R ;
Friday, G ;
Furie, K ;
Gorelick, P ;
Kissela, B ;
Marler, J ;
Meigs, J ;
Roger, V ;
Sidney, S ;
Sorlie, P ;
Steinberger, J ;
Wasserthiel-Smoller, S ;
Wilson, M ;
Wolf, P .
CIRCULATION, 2006, 113 (06) :E85-E151
[8]   Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis [J].
Wang, Q ;
Rao, SQ ;
Shen, GQ ;
Li, L ;
Moliterno, DJ ;
Newby, LK ;
Rogers, WJ ;
Cannata, R ;
Zirzow, E ;
Elston, RC ;
Topol, EJ .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (02) :262-271
[9]   Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins [J].
Zdravkovic, S ;
Wienke, A ;
Pedersen, NL ;
Marenberg, ME ;
Yashin, AI ;
De Faire, U .
JOURNAL OF INTERNAL MEDICINE, 2002, 252 (03) :247-254
[10]   Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches [J].
Zintzaras, Elias ;
Kitsios, Georgios .
JOURNAL OF HUMAN GENETICS, 2006, 51 (11) :1015-1021
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