High-Throughput Proteomics

被引：198

作者：

Zhang, Zhaorui ^{[1
]}

Wu, Si ^{[1
]}

Stenoien, David L. ^{[2
]}

Pasa-Tolic, Ljiljana ^{[1
]}

机构：

[1] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA

[2] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99352 USA

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 7 | 2014年 / 7卷

关键词：

proteomics; mass spectrometry; liquid chromatography; ion-mobility spectrometry; PHASE LIQUID-CHROMATOGRAPHY; ION-CYCLOTRON RESONANCE; ELECTRON-TRANSFER DISSOCIATION; TANDEM MASS-SPECTROMETRY; COMPLEX PROTEIN MIXTURES; TOP-DOWN IDENTIFICATION; TIME-OF-FLIGHT; INFRARED MULTIPHOTON DISSOCIATION; INCREASED DYNAMIC-RANGE; LARGE-SCALE ANALYSIS;

D O I：

10.1146/annurev-anchem-071213-020216

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Mass spectrometry (MS)-based high-throughput proteomics is the core technique for large-scale protein characterization. Due to the extreme complexity of proteomes, sophisticated separation techniques and advanced MS instrumentation have been developed to extend coverage and enhance dynamic range and sensitivity. In this review, we discuss the separation and prefractionation techniques applied for large-scale analysis in both bottom-up (i. e., peptide-level) and top-down (i. e., protein-level) proteomics. Different approaches for quantifying peptides or intact proteins, including label-free and stable-isotope-labeling strategies, are also discussed. In addition, we present a brief overview of different types of mass analyzers and fragmentation techniques as well as selected emerging techniques.

引用

页码：427 / 454

页数：28

共 176 条

[1] The human plasma proteome - History, character, and diagnostic prospects [J].

Anderson, NL ;

Anderson, NG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867

[2] A new algorithm using cross-assignment for label-free quantitation with LC-LTQ-FT MS [J].

Andreev, Victor P. ;

Li, Lingyun ;

Cao, Lei ;

Gu, Ye ;

Rejtar, Tomas ;

Wu, Shiaw-Lin ;

Karger, Barry L. .

JOURNAL OF PROTEOME RESEARCH, 2007, 6 (06) :2186-2194

[3] Performance Characteristics of a New Hybrid Quadrupole Time-of-Flight Tandem Mass Spectrometer (TripleTOF 5600) [J].

Andrews, Genna L. ;

Simons, Brigitte L. ;

Young, J. Bryce ;

Hawkridge, Adam M. ;

Muddiman, David C. .

ANALYTICAL CHEMISTRY, 2011, 83 (13) :5442-5446

[4] Mass spectrometry-based proteomics: existing capabilities and future directions [J].

Angel, Thomas E. ;

Aryal, Uma K. ;

Hengel, Shawna M. ;

Baker, Erin S. ;

Kelly, Ryan T. ;

Robinson, Errol W. ;

Smith, Richard D. .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (10) :3912-3928

[5] Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typhimurium in response to infection-like conditions [J].

Ansong, Charles ;

Wu, Si ;

Meng, Da ;

Liu, Xiaowen ;

Brewer, Heather M. ;

Kaiser, Brooke L. Deatherage ;

Nakayasu, Ernesto S. ;

Cort, John R. ;

Pevzner, Pavel ;

Smith, Richard D. ;

Heffron, Fred ;

Adkins, Joshua N. ;

Pasa-Tolic, Ljiljana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (25) :10153-10158

[6] Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening [J].

Bachovchin, Daniel A. ;

Ji, Tianyang ;

Li, Weiwei ;

Simon, Gabriel M. ;

Blankman, Jacqueline L. ;

Adibekian, Alexander ;

Hoover, Heather ;

Niessen, Sherry ;

Cravatt, Benjamin F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (49) :20941-20946

[7] An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput Proteomic Studies [J].

Baker, Erin Shammel ;

Livesay, Eric A. ;

Orton, Daniel J. ;

Moore, Ronald J. ;

Danielson, William F., III ;

Prior, David C. ;

Ibrahim, Yehia M. ;

LaMarche, Brian L. ;

Mayampurath, Anoop M. ;

Schepmoes, Athena A. ;

Hopkins, Derek F. ;

Tang, Keqi ;

Smith, Richard D. ;

Belov, Mikhail E. .

JOURNAL OF PROTEOME RESEARCH, 2010, 9 (02) :997-1006

[8] Shift Reagents for Multidimensional Ion Mobility Spectrometry-Mass Spectrometry Analysis of Complex Peptide Mixtures: Evaluation of 18-Crown-6 Ether Complexes [J].

Bohrer, Brian C. ;

Clemmer, David E. .

ANALYTICAL CHEMISTRY, 2011, 83 (13) :5377-5385

[9] Significant Modifications of the Salivary Proteome Potentially Associated with Complications of Down Syndrome Revealed by Top-down Proteomics [J].

Cabras, Tiziana ;

Pisano, Elisabetta ;

Montaldo, Caterina ;

Giuca, Maria Rita ;

Iavarone, Federica ;

Zampino, Giuseppe ;

Castagnola, Massimo ;

Messana, Irene .

MOLECULAR & CELLULAR PROTEOMICS, 2013, 12 (07) :1844-1852

[10] Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes [J].

Cabras, Tiziana ;

Pisano, Elisabetta ;

Mastinu, Andrea ;

Denotti, Gloria ;

Pusceddu, Pietro Paolo ;

Inzitari, Rosanna ;

Fanali, Chiara ;

Nemolato, Sonia ;

Castagnola, Massimo ;

Messana, Irene .

MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (10) :2099-2108

← 1 2 3 4 5 6 7 8 9 10 →