Microtubule plus-end tracking proteins in neuronal development

被引：63

作者：

van de Willige, Dieudonnee ^{[1
]}

Hoogenraad, Casper C. ^{[1
]}

Akhmanova, Anna ^{[1
]}

机构：

[1] Univ Utrecht, Fac Sci, Cell Biol, Padualaan 8, NL-3584 CH Utrecht, Netherlands

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2016年 / 73卷 / 10期

关键词：

Neuron; Development; Polarity; Cytoskeleton; Microtubule; Plus; end tracking proteins; EB; CLIP; CLASP; ADENOMATOUS POLYPOSIS-COLI; TAU-TUBULIN KINASE; INTERKINETIC NUCLEAR MIGRATION; PROMOTES AXON ELONGATION; DYSTONIN ISOFORM 2; NEURITE OUTGROWTH; BINDING-PROTEINS; DYNAMIC MICROTUBULES; NERVOUS-SYSTEM; CELL-MIGRATION;

D O I：

10.1007/s00018-016-2168-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

引用

页码：2053 / 2077

页数：25

共 284 条

[41] Axon injury and stress trigger a microtubule-based neuroprotective pathway [J].

Chen, Li ;

Stone, Michelle C. ;

Tao, Juan ;

Rolls, Melissa M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (29) :11842-11847

[42] Axon Regeneration Pathways Identified by Systematic Genetic Screening in C. elegans [J].

Chen, Lizhen ;

Wang, Zhiping ;

Ghosh-Roy, Anindya ;

Hubert, Thomas ;

Yan, Dong ;

O'Rourke, Sean ;

Bowerman, Bruce ;

Wu, Zilu ;

Jin, Yishi ;

Chisholm, Andrew D. .

NEURON, 2011, 71 (06) :1043-1057

[43]

Chen YT, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0023237, 10.1371/journal.pone.0017876]

[44] CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex [J].

Chen, Yi-Kai ;

Chen, Chiung-Ya ;

Hu, Hsiao-Tang ;

Hsueh, Yi-Ping .

MOLECULAR BIOLOGY OF THE CELL, 2012, 23 (22) :4383-4392

[45] Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance [J].

Chen, Yi-Kai ;

Hsueh, Yi-Ping .

JOURNAL OF NEUROSCIENCE, 2012, 32 (03) :1043-1055

[46] Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling [J].

Cheng, Long ;

Desai, Jigar ;

Miranda, Carlos J. ;

Duncan, Jeremy S. ;

Qiu, Weihong ;

Nugent, Alicia A. ;

Kolpak, Adrianne L. ;

Wu, Carrie C. ;

Drokhlyansky, Eugene ;

Delisle, Michelle M. ;

Chan, Wai-Man ;

Wei, Yan ;

Propst, Friedrich ;

Reck-Peterson, Samara L. ;

Fritzsch, Bernd ;

Engle, Elizabeth C. .

NEURON, 2014, 82 (02) :334-349

[47] Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 [J].

Cheung, J ;

Petek, E ;

Nakabayashi, K ;

Tsui, LC ;

Vincent, JB ;

Scherer, SW .

GENOMICS, 2001, 78 (1-2) :7-11

[48] SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis [J].

Chin, LS ;

Nugent, RD ;

Raynor, MC ;

Vavalle, JP ;

Li, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :1191-1200

[49] Microtubule assembly, organization and dynamics in axons and dendrites [J].

Conde, Cecilia ;

Caceres, Alfredo .

NATURE REVIEWS NEUROSCIENCE, 2009, 10 (05) :319-332

[50] LIS1, CLIP-170's key to the dynein/dynactin pathway [J].

Coquelle, FM ;

Caspi, M ;

Cordelières, FP ;

Dompierre, JP ;

Dujardin, DL ;

Koifman, C ;

Martin, P ;

Hoogenraad, CC ;

Akhmanova, A ;

Galjart, N ;

De Mey, JR ;

Reiner, O .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (09) :3089-3102

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