Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

被引：592

作者：

Kourembanas, Stella ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Div Newborn Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF PHYSIOLOGY, VOL 77 | 2015年 / 77卷

关键词：

mesenchymal stem cells; microRNA; lung vascular disease; regenerative medicine; secretome; MESENCHYMAL STEM-CELLS; TUMOR-DERIVED EXOSOMES; VERSUS-HOST-DISEASE; BRONCHOALVEOLAR LAVAGE FLUID; ACUTE MYOCARDIAL-INFARCTION; STROMAL CELLS; ENDOTHELIAL-CELLS; IN-VITRO; T-CELLS; ISCHEMIA/REPERFUSION INJURY;

D O I：

10.1146/annurev-physiol-021014-071641

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine, are being widely tested for the treatment of a variety of human diseases. No one factor has been proven sufficient to mediate the therapeutic effects of MSCs. However, exosomes-membrane vesicles secreted by many cells, including MSCs-are appealing candidates as vectors of their efficacy. Exosomes can transport and deliver a large cargo of proteins, lipids, and nucleic acids and can modify cell and organ function. In addition to their key role as vehicles of intercellular communication, exosomes are increasingly recognized as biomarkers and prognosticators of disease. Moreover, they have the potential to be used as vehicles of gene and drug delivery for clinical application. This article reviews the biogenesis of exosomes, their molecular composition, and their role as messengers of intercellular communication, focusing on their potential as therapeutic vectors for stem cell therapy.

引用

页码：13 / 27

页数：15

共 104 条

[51] Sonic Hedgehog-Modified Human CD34+Cells Preserve Cardiac Function After Acute Myocardial Infarction [J].

Mackie, Alexander R. ;

Klyachko, Ekaterina ;

Thorne, Tina ;

Schultz, Kathryn M. ;

Millay, Meredith ;

Ito, Aiko ;

Kamide, Christine E. ;

Liu, Ting ;

Gupta, Rajesh ;

Sahoo, Susmita ;

Misener, Sol ;

Kishore, Raj ;

Losordo, Douglas W. .

CIRCULATION RESEARCH, 2012, 111 (03) :312-+

[52] Exosomes from human saliva as a source of microRNA biomarkers [J].

Michael, A. ;

Bajracharya, S. D. ;

Yuen, P. S. T. ;

Zhou, H. ;

Star, R. A. ;

Illei, G. G. ;

Alevizos, I. .

ORAL DISEASES, 2010, 16 (01) :34-38

[53] Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells [J].

Mittelbrunn, Maria ;

Gutierrez-Vazquez, Cristina ;

Villarroya-Beltri, Carolina ;

Gonzalez, Susana ;

Sanchez-Cabo, Fatima ;

Angel Gonzalez, Manuel ;

Bernad, Antonio ;

Sanchez-Madrid, Francisco .

NATURE COMMUNICATIONS, 2011, 2

[54] Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells [J].

Nakagami, H ;

Maeda, K ;

Morishita, R ;

Iguchi, S ;

Nishikawa, T ;

Takami, Y ;

Kikuchi, Y ;

Saito, Y ;

Tamai, K ;

Ogihara, T ;

Kaneda, Y .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (12) :2542-2547

[55] Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer [J].

Nilsson, J. ;

Skog, J. ;

Nordstrand, A. ;

Baranov, V. ;

Mincheva-Nilsson, L. ;

Breakefield, X. O. ;

Widmark, A. .

BRITISH JOURNAL OF CANCER, 2009, 100 (10) :1603-1607

[56] RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls [J].

Noerholm, Mikkel ;

Balaj, Leonora ;

Limperg, Tobias ;

Salehi, Afshin ;

Zhu, Lin Dan ;

Hochberg, Fred H. ;

Breakefield, Xandra O. ;

Carter, Bob S. ;

Skog, Johan .

BMC CANCER, 2012, 12

[57] Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury [J].

Ortiz, Luis A. ;

DuTreil, Maria ;

Fattman, Cheryl ;

Pandey, Amitabh C. ;

Torres, German ;

Go, Kristina ;

Phinney, Donald G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :11002-11007

[58] FATE OF THE TRANSFERRIN RECEPTOR DURING MATURATION OF SHEEP RETICULOCYTES INVITRO - SELECTIVE EXTERNALIZATION OF THE RECEPTOR [J].

PAN, BT ;

JOHNSTONE, RM .

CELL, 1983, 33 (03) :967-977

[59] The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities [J].

Pant, Saumya ;

Hilton, Holly ;

Burczynski, Michael E. .

BIOCHEMICAL PHARMACOLOGY, 2012, 83 (11) :1484-1494

[60] Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure [J].

Parekkadan, Biju ;

van Poll, Daan ;

Suganuma, Kazuhiro ;

Carter, Edward A. ;

Berthiaume, Francois ;

Tilles, Arno W. ;

Yarmush, Martin L. .

PLOS ONE, 2007, 2 (09)

← 1 2 3 4 5 6 7 8 9 10 →