T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

被引:82
作者
Jain, Aakanksha [1 ]
Song, Ran [1 ]
Wakeland, Edward K. [1 ]
Pasare, Chandrashekhar [1 ,2 ]
机构
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Cincinnati, OH 45229 USA
来源
NATURE COMMUNICATIONS | 2018年 / 9卷
基金
美国国家卫生研究院;
关键词
T(H)17 CELLS; ADAPTIVE IMMUNITY; CLONAL EXPANSION; CROSS-REACTIVITY; INTERFERON-GAMMA; HELPER-CELLS; INNATE; TH1; DIFFERENTIATION; ACTIVATION;
D O I
10.1038/s41467-018-05489-7
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Innate cytokines are critical drivers of priming and differentiation of naive CD4 T cells, but their functions in memory T cell response are largely undefined. Here we show that IL-1 acts as a licensing signal to permit effector cytokine production by pre-committed Th1 (IFN-gamma), Th2 (IL-13, IL-4, and IL-5) and Th17 (IL-17A, IL-17F, and IL-22) lineage cells. This licensing function of IL-1 is conserved across effector CD4 T cells generated by diverse immunological insults. IL-1R signaling stabilizes cytokine transcripts to enable productive and rapid effector functions. We also demonstrate that successful lineage commitment does not translate into productive effector functions in the absence of IL-1R signaling. Acute abrogation of IL-1R signaling in vivo results in reduced IL-17A production by intestinal Th17 cells. These results extend the role of innate cytokines beyond CD4 T cell priming and establish IL-1 as a licensing signal for memory CD4 T cell function.
引用
收藏
页数:13
相关论文
共 71 条
  • [1] Post-transcriptional control of cytokine production
    Anderson, Paul
    [J]. NATURE IMMUNOLOGY, 2008, 9 (04) : 353 - 359
  • [2] ATP drives lamina propria TH17 cell differentiation
    Atarashi, Koji
    Nishimura, Junichi
    Shima, Tatsuichiro
    Umesaki, Yoshinori
    Yamamoto, Masahiro
    Onoue, Masaharu
    Yagita, Hideo
    Ishii, Naoto
    Evans, Richard
    Honda, Kenya
    Takeda, Kiyoshi
    [J]. NATURE, 2008, 455 (7214) : 808 - U10
  • [3] Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells
    Bachmann, MF
    Gallimore, A
    Linkert, S
    Cerundolo, V
    Lanzavecchia, A
    Kopf, M
    Viola, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (10) : 1521 - 1529
  • [4] IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance
    Basu, Rajatava
    Whitley, Sarah K.
    Bhaumik, Suniti
    Zindl, Carlene L.
    Schoeb, Trenton R.
    Benveniste, Etty N.
    Pear, Warren S.
    Hatton, Robin D.
    Weaver, Casey T.
    [J]. NATURE IMMUNOLOGY, 2015, 16 (03) : 286 - U252
  • [5] Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria
    Basu, Rajatava
    O'Quinn, Darrell B.
    Silberger, Daniel J.
    Schoeb, Trenton R.
    Fouser, Lynette
    Ouyang, Wenjun
    Hatton, Robin D.
    Weaver, Casey T.
    [J]. IMMUNITY, 2012, 37 (06) : 1061 - 1075
  • [6] IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
    Ben-Sasson, Shlomo Z.
    Hu-Li, Jane
    Quiel, Juan
    Cauchetaux, Stephane
    Ratner, Maya
    Shapira, Ilana
    Dinarello, Charles A.
    Paul, William E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (17) : 7119 - 7124
  • [7] Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen
    Berg, RE
    Crossley, E
    Murray, S
    Forman, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (10) : 1583 - 1593
  • [8] Deconstructing the Peptide-MHC Specificity of T Cell Recognition
    Birnbaum, Michael E.
    Mendoza, Juan L.
    Sethi, Dhruv K.
    Dong, Shen
    Glanville, Jacob
    Dobbins, Jessica
    Oezkan, Engin
    Davis, Mark M.
    Wucherpfennig, Kai W.
    Garcia, K. Christopher
    [J]. CELL, 2014, 157 (05) : 1073 - 1087
  • [9] IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 Cultures
    Blom, Lars
    Poulsen, Lars K.
    [J]. JOURNAL OF IMMUNOLOGY, 2012, 189 (09) : 4331 - 4337
  • [10] Memory T cells need CD28 costimulation to remember
    Boesteanu, Alina C.
    Katsikis, Peter D.
    [J]. SEMINARS IN IMMUNOLOGY, 2009, 21 (02) : 69 - 77