The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder

被引：22

作者：

Amidfar, Meysam ^{[1
]}

Reus, Gislaine Zilli ^{[2
]}

de Moura, Airam Barbosa ^{[2
]}

Quevedo, Joao ^{[3
,4
]}

Kim, Yong-Ku ^{[5
]}

机构：

[1] Univ Tehran Med Sci, Tehran, Iran

[2] Univ Southern Santa Catarina, Grad Program Hlth Sci, Translat Psychiat Lab, Criciuma, SC, Brazil

[3] McGovern Med Sch, UT Hlth Ctr Excellence Mood Disorders, Faillace Dept Psychiat & Behav Sci, Houston, TX USA

[4] McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

[5] Korea Univ Ansan Hosp, Coll Med, Dept Psychiat, Ansan, South Korea

来源：

MAJOR DEPRESSIVE DISORDER: RETHINKING AND UNDERSTANDING RECENT DISCOVERIES | 2021年 / 1305卷

关键词：

Neurotrophins; Neuroplasticity; Brain-derived neurotrophic factor; Glial cell-derived neurotrophic factor; Major depressive disorder; ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; ADULT HIPPOCAMPAL NEUROGENESIS; LONG-TERM DEPRESSION; GENE-EXPRESSION; POSTMORTEM BRAIN; FACTOR SYSTEM; FACTOR VEGF; IGF-I; STIMULATES NEUROGENESIS;

D O I：

10.1007/978-981-33-6044-0_14

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

According to the neurotrophic hypothesis of major depressive disorder (MDD), impairment in growth factor signaling might be associated with the pathology of this illness. Current evidence demonstrates that impaired neuroplasticity induced by alterations of neurotrophic growth factors and related signaling pathways may be underlying to the pathophysiology of MDD. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophic factor involved in the neurobiology of MDD. Nevertheless, developing evidence has implicated other neurotrophic factors, including neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), glial cell-derived neurotrophic factor (GDNF), and fibroblast growth factor (FGF) in the MDD pathophysiology. Here, we summarize the current literature on the involvement of neurotrophic factors and related signaling pathways in the pathophysiology of MDD.

引用

页码：257 / 272

页数：16

共 131 条

[1] GDNF family neurotrophic factor signaling: Four masters, one servant? [J].