Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium

被引：85

作者：

Tsai, IL

Lin, WY

Teng, CM

Ishikawa, T

Doong, SL

Huang, MW

Chen, YC

Chen, IS ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan

[2] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 10764, Taiwan

[3] Fac Pharmaceut Sci, Chiba, Japan

[4] Natl Taiwan Univ, Coll Med, Grad Inst Microbiol, Taipei 10764, Taiwan

来源：

PLANTA MEDICA | 2000年 / 66卷 / 07期

关键词：

Zanthoxylum schinifolium; Rutaceae; root bark; coumarin; terpenyl-coumarins; alkaloids; furoquinolines; antiplatelet aggregation activity; anti-HBV DNA replication;

D O I：

10.1055/s-2000-8648

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Further study an the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallyloI (4), hydroxyepoxycollinin ii (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.

引用

页码：618 / 623

页数：6

共 20 条

[1] CONSTITUENTS OF TROPICAL MEDICINAL PLANTS .51. EPOXYCHIROMODINE AND OTHER CONSTITUENTS OF CROTON-MEGALOCARPUS [J].