Mechanisms of hematopoietic stem cell aging

被引：53
作者：
Ergen, Aysegul V. [2 ]
Goodell, Margaret A. [1 ,2 ]
机构：
[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA
[2] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2010年 / 45卷 / 04期
关键词：
Hematopoietic stem cell; Aging; Gene expression; Epigenetics; Reactive oxygen species; Niche; PROGENITOR CELLS; OXIDATIVE STRESS; AGE; LOCUS; NICHE; MICE; PROLIFERATION; MAINTENANCE; DISEASES; NUMBER;
D O I：
10.1016/j.exger.2009.12.010
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
New blood cells are continually produced from the hematopoietic stem cells (HSCs) that reside in the bone marrow. Throughout the life-span of the organism, this stem cell reservoir sustains life. Although HSCs can persist in vivo longer than one life-span (Harrison et al., 1978), with aging, HSC regenerative potential diminishes and skewing from lymphopoiesis toward myelopoiesis occurs. The expansion in the HSC pool with aging provides sufficient, yet abnormal, blood production. Examination of gene expression changes in aged HSCs has provided a link between aging and genomic instability. Furthermore, studies on the effects of reactive oxygen species (ROS) on HSC aging has given more insight into the reasons for HSC failure. Understanding of the interactions between niche cells and HSCs and changes in them with aging, may give us insights into the lineage skewing phenotype observed in the aged, and also other immune dysfunctions. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：286 / 290
页数：5
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