Recent Advances in Endogenous and Exogenous Stimuli-Responsive Nanocarriers for Drug Delivery and Therapeutics

被引：66
作者：
Hatakeyama, Hiroto [1 ]
机构：
[1] Chiba Univ, Lab Clin Pharmacol & Pharmacometr, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2017年 / 65卷 / 07期
关键词：
drug delivery system; liposome; hyperthermia; stimuli-triggered release; cancer therapy; ENVELOPE-TYPE NANOPARTICLE; LIPID-LIKE MATERIAL; SENSITIVE FUSOGENIC PEPTIDE; BLOCK-COPOLYMER MICELLES; EFFICIENT SIRNA DELIVERY; IN-VIVO; GENE DELIVERY; PLASMID DNA; HEPATOCELLULAR-CARCINOMA; CLEAVABLE LIPOPOLYMERS;
D O I：
10.1248/cpb.c17-00068
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Significant progress has been achieved in the development of stimuli-responsive nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized in the development of nanocarrier delivery. Endogenous factors such as changes in pH, redox, gradient, and enzyme concentration which are linked to disease progression have been utilized for controlling biodistribution and releasing drugs from nanocarriers, as well as increasing subsequent pharmacological activity at the disease site. Nanocarriers which respond to artificially-induced exogenous factors (such as temperature, light, magnetic field, and ultrasound) have also been developed. This review aims to discuss recent advances in the design of stimuli-responsive nanocarriers which appear to have a promising future in medicine.
引用
收藏
页码：612 / 617
页数：6
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